14,441 Genomics-Based Validated Automated Comprehensive Clinicopathologic Correlations for Myeloid Neoplasms

Ahmed Elsafty, PathOlOgics, LLC, Cairo, Egypt. aelnady777@hotmail.com.
Yomna Ahmed, PathOlOgics, LLC, Cairo, Egypt.
Taher F. Halawa, Pediatric Hematology-Oncology Department, Aberdeen Hospital, Nova Scotia Health Authority, Halifax, Canada.
Shaoguang Li, Hematology/Oncology Division, Department of Medicine, Medical School, University of Massachusetts Chan, Worcester, MA, USA.
Dongguang Li, Hematology/Oncology Division, Department of Medicine, Medical School, University of Massachusetts Chan, Worcester, MA, USA.
Elena Agranovsky, Lenco Diagnostic Lab, NYC, Brooklyn, USA.
Ahmed Soliman, PathOlOgics, LLC, Cairo, Egypt. a.m.montasser@outlook.com.
Howida Talaat, PathOlOgics, LLC, Cairo, Egypt.
Mohamed Montaser, PathOlOgics, LLC, Cairo, Egypt.
Omar Elnady, PathOlOgics, LLC, Cairo, Egypt.
Deyaa Elnady, Database Academy, Cairo, Egypt.
Mohamed Mahmoud Moustafa, Department of Data Science, New Jersey Institute of Technology, Newark, USA.
Nourhan Ibrahim, Anatomic & Clinical Pathology Department, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, USA.
Maryana Gumenyak, NYC Health+Hospitals South Brooklyn Health, Brooklyn, NY, USA.
Yasmin Soliman, Geriatric & Family Medicine Department, Dubai Academic Health Corporation, Dubai, UAE.
Samah Ali, Pathology Department, University of Toledo Medical Center, Toledo, USA.
Elshaimaa Abdelrahman, Pathology Department, The George Washington University, Washington, DC, USA.
Hatem M. Alahwal, Department of Hematology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Ahmed S. Barefah, Department of Hematology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Ashraf Abdelghany, Biomedical Research Centre (CIBM), Granada Medical School, Granada, Spain.
Sherif Ammar, Obstetrics and Gynecology Department, Worcestershire Acute Hospitals NHS Trust, Worcester, UK.
Nermeen Abdel-Haleem, Regional Laboratory, Taif, Saudi Arabia.
Osama Abdel-Kareem, Otolaryngology Department, Saudi German Hospitals, Jeddah, Saudi Arabia.
Samir N. Shamma, Institute of Global Health & Human Ecology, School of Sciences & Engineering, The American University in Cairo, Cairo, Egypt.
Naglaa Husein, Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Maha M. Sakr, Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Heba-Allah E. AbdElrhman, Clinical Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Menatalla Nadim, Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Hany Girguis, Clinical Pathology Department, Children Cancer Hospital (CCHE) 57357, Cairo, Egypt.
Manal Othman, Clinical Pathology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt.
Ola Soliman, Clinical Pathology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt.
Walaa H. Behery, Clinical Pathology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt.

Document Type

Journal Article

Publication Date

11-19-2025

Journal

Scientific data

Volume

12

Issue

1

DOI

10.1038/s41597-025-06284-y

Abstract

The dataset (Elsafty_Reports_of_Myeloid_Neoplasms_2024) consists of 14,441 comprehensive clinicopathologic correlations (CPCs) for myeloid neoplasms (MN) with corresponding laboratory results. Specialized online platform utilizing these laboratory results automatically generated the diagnostic and prognostic CPCs. These results include complete blood counts (CBC), peripheral blood smear (PBS) findings, blast/promyelocyte count with dysplasia screening by flow cytometry, and molecular results by NGS/PCR. Two Hematopathologists, who performed the CBC and PBS review, collected their 10,794 real-world reports of cases served in Egypt with molecular studies performed in the USA and Europe. These newly-diagnosed cases included 243 chronic myeloid leukemia (CML) cases with 257 mutations/aberrations; 4,567 non-CML MN cases with 7,883 Tiers I/II mutations/aberrations, amino acid changes, and allele frequencies; and 5,984 benign/inconclusive cases with negative NGS for myeloid mutations/aberrations in 66 DNA/RNA genes. Additionally, there are 3,647 CPCs with synthetic genomics simulating all new/follow-up CML cases and complex/rare non-CML MN cases. Stringent validation by 51 international professors/consultants/specialists from multiple medical centres confirmed 100% medical and clerical accuracy, referencing the WHO 5th edition and relevant esteemed publications.

Department

School of Medicine and Health Sciences Resident Works

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