Biological Regulation of HIF-1α and Its Role in Therapeutic Angiogenesis for Treatment of Ischemic Cardiovascular Disease

Authors

Ethan Carmichael, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Anne-Isabelle S. Reme, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Patrick J. Bosco, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Yulexi Y. Ortiz, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Daniela Alexandra Ramos, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Katherine Gomez, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Bao-Ngoc Nguyen, Department of Surgery, The George Washington University School of Medicine and Health Sciences, Washington DC 20037, USA.
Arash Bornak, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Zhao-Jun Liu, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Omaida C. Velazquez, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Document Type

Journal Article

Publication Date

11-20-2025

Journal

International journal of molecular sciences

Volume

26

Issue

22

DOI

10.3390/ijms262211236

Keywords

HIF-1α; cardiovascular diseases; hypoxia; ischemia; oxygen

Abstract

Hypoxia, characterized by insufficient oxygen saturation, triggers a wide array of vascular responses aimed at enhancing cell survival and proliferation. This process is primarily driven by the activation of oxygen-sensing hypoxia-inducible factors (HIFs). HIF-1α, a key mediator in this context, plays a crucial role in vascular restructuring in response to low oxygen tension and oxygen-independent signaling pathways, making it a promising therapeutic target for ischemic cardiovascular diseases such as peripheral artery disease and coronary artery disease. In this review, we explore both oxygen-dependent and oxygen-independent mechanisms of HIF-1α regulation, the role of the HIF protein family in vessel collateralization, and translational efforts to leverage HIF-1α's pivotal role in hypoxia signaling for the development of clinical treatments for ischemic cardiovascular disease.

APA Citation

Carmichael, Ethan; Reme, Anne-Isabelle S.; Bosco, Patrick J.; Ortiz, Yulexi Y.; Ramos, Daniela Alexandra; Gomez, Katherine; Nguyen, Bao-Ngoc; Bornak, Arash; Liu, Zhao-Jun; and Velazquez, Omaida C., "Biological Regulation of HIF-1α and Its Role in Therapeutic Angiogenesis for Treatment of Ischemic Cardiovascular Disease" (2025). GW Authored Works. Paper 8077.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/8077

Department

Surgery