Rash and edema shortly after initial exposure to low dose cenobamate

Authors

Christopher Saouda, Department of Neurology, George Washington University, Washington, DC, USA.
Yamane Makke, Department of Neurology, George Washington University, Washington, DC, USA.
Helen Edelberg, Department of Neurology, George Washington University, Washington, DC, USA.
Mohamad Z. Koubeissi, Department of Neurology, George Washington University, Washington, DC, USA.

Document Type

Journal Article

Publication Date

9-1-2025

Journal

Epilepsy & behavior reports

Volume

31

DOI

10.1016/j.ebr.2025.100800

Keywords

Adverse effects; Cenobamate; Edema; Epilepsy; Rash

Abstract

Cenobamate (CNB) is an antiseizure medication (ASM) approved for the treatment of focal epilepsy. Rash and edema are uncommon adverse effects of this medication. We report two patients with medically refractory epilepsy (MRE) who received CNB and developed chest and facial rash and edema after the initial dose of 12.5 mg/d that prompted discontinuation of the medication with ensuing resolution of the rash and edema. Rechallenging with CNB resulted in similar reactions. Our report aims at increasing awareness of these reactions to CNB.

APA Citation

Saouda, Christopher; Makke, Yamane; Edelberg, Helen; and Koubeissi, Mohamad Z., "Rash and edema shortly after initial exposure to low dose cenobamate" (2025). GW Authored Works. Paper 8029.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/8029

Department

Neurology