Papillary renal neoplasm with reverse polarity: a case report and literature review

Authors

Diego Gonzalez, Department of Urology, George Washington University School of Medicine, Washington, DC, United States.
Kris Kokoneshi, Department of Urology, George Washington University School of Medicine, Washington, DC, United States.
Sam Kwon, Department of Urology, George Washington University School of Medicine, Washington, DC, United States.
Ryan Thomas Mathews, Department of Urology, George Washington University School of Medicine, Washington, DC, United States.
Ryan Michael Antar, Department of Urology, George Washington University School of Medicine, Washington, DC, United States.
Maher Ali, Department of Pathology, George Washington University School of Medicine, Washington, DC, United States.
Abiye Kassa, Department of Pathology, George Washington University School of Medicine, Washington, DC, United States.
Michael Whalen, Department of Urology, George Washington University School of Medicine, Washington, DC, United States.

Document Type

Journal Article

Publication Date

1-1-2025

Journal

Frontiers in oncology

Volume

15

DOI

10.3389/fonc.2025.1598738

Keywords

oncology; papillary renal neoplasm with reverse polarity (PRNRP); renal cancer; renal cell carcinoma; renal neoplasm

Abstract

INTRODUCTION: Papillary renal neoplasm with reverse polarity (PRNRP) is a rare subtype of papillary renal cell carcinoma (RCC) with unique morphology, molecular features, and good prognosis. Given its rarity, with less than 100 reported cases, further characterization is needed to enhance diagnostic accuracy and inform management strategies. CASE PRESENTATION: We report the case of a 59-year-old African American female with an incidentally discovered 2.1 cm left renal mass on imaging. The patient has a medical history of hypertension, asthma, hyperlipidemia, vertigo, depression/anxiety, and prediabetes. Further evaluation via contrast-enhanced CT confirmed an enhancing renal mass without evidence of metastasis. She underwent a robotic-assisted partial nephrectomy, and postoperative pathology confirmed PRNRP with pT1aNxMxR0 staging and ISUP nuclear grade 1. Immunohistochemical analysis demonstrated positive staining for GATA3, CK7, and EMA, and Vimentin and negative for AMACR and CA IX. Molecular profiling revealed a KRAS mutation, a key feature of PRNRP. Postoperative recovery was uneventful aside from transient vertigo, and no further treatment was required. CONCLUSION: This case reinforces the distinct morphological and molecular profile of PRNRP, distinguishing it from other papillary RCC subtypes. The indolent behavior, absence of metastatic cases, and characteristic molecular profiling and immunohistochemical markers highlight the importance of accurate classification for optimal patient management. Furthermore, the PD-L1 positivity observed in this case raises potential implications for immune checkpoint therapy, an area warranting further investigation. As PRNRP is recently classified, continued study is essential to refine diagnostic, therapeutic, and surveillance strategies for this rare renal neoplasm.

APA Citation

Gonzalez, Diego; Kokoneshi, Kris; Kwon, Sam; Mathews, Ryan Thomas; Antar, Ryan Michael; Ali, Maher; Kassa, Abiye; and Whalen, Michael, "Papillary renal neoplasm with reverse polarity: a case report and literature review" (2025). GW Authored Works. Paper 7978.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/7978

Department

School of Medicine and Health Sciences Student Works