Naturalistic driving measures of route selection associate with resting state networks in older adults
Authors
Julie K. Wisch, Department of Neurology, Washington University in Saint Louis School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
Catherine M. Roe, Department of Neurology, Washington University in Saint Louis School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
Ganesh M. Babulal, Department of Neurology, Washington University in Saint Louis School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
Nicholas Metcalf, Department of Neurology, Washington University in Saint Louis School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
Ann M. Johnson, Center for Clinical Studies, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Samantha Murphy, Department of Neurology, Washington University in Saint Louis School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
Jamie Hicks, Department of Neurology, Washington University in Saint Louis School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
Jason M. Doherty, Department of Neurology, Washington University in Saint Louis School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
John C. Morris, Department of Neurology, Washington University in Saint Louis School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.
Beau M. Ances, Department of Neurology, Washington University in Saint Louis School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA. bances@wustl.edu.
Document Type
Journal Article
Publication Date
4-20-2022
Journal
Scientific reports
DOI
10.1038/s41598-022-09919-x
Abstract
Our objective was to identify functional brain changes that associate with driving behaviors in older adults. Within a cohort of 64 cognitively normal adults (age 60+), we compared naturalistic driving behavior with resting state functional connectivity using machine learning. Functional networks associated with the ability to interpret and respond to external sensory stimuli and the ability to multi-task were associated with measures of route selection. Maintenance of these networks may be important for continued preservation of driving abilities.
APA Citation
Wisch, Julie K.; Roe, Catherine M.; Babulal, Ganesh M.; Metcalf, Nicholas; Johnson, Ann M.; Murphy, Samantha; Hicks, Jamie; Doherty, Jason M.; Morris, John C.; and Ances, Beau M., "Naturalistic driving measures of route selection associate with resting state networks in older adults" (2022). GW Authored Works. Paper 772.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/772
Department
Clinical Research and Leadership
