Unstuck and on target! for children with neurofibromatosis type 1: a feasibility and acceptability study

Document Type

Journal Article

Publication Date

8-27-2025

Journal

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence

DOI

10.1080/09297049.2025.2549017

Keywords

Neurofibromatosis type 1; cognitive rehabilitation; executive function; feasibility studies; neuropsychology

Abstract

Children with Neurofibromatosis Type 1 (NF1) experience significant executive dysfunction interfering with outcomes across the lifespan. To date, there have been limited interventions targeting executive function impairments, and even less explored within the NF1 population. The primary purpose of this study was to determine if an existing executive functioning intervention, Unstuck and On Target! (UOT), is a feasible and acceptable intervention for children with NF1. Participants were four children with NF1 (75% male; 75% Caucasian) between the ages of 9 to 12 years and their parents. Participants engaged in 20 weekly group sessions of UOT over the course of five months. Attendance rates and satisfaction ratings were primary outcomes. Attendance was >95% and attrition was null. Parent feedback and satisfaction ratings were overwhelmingly positive. In the first study of its kind, the results suggest that UOT is a feasible and acceptable cognitive intervention for children with NF1. Future development of Phase II/III studies of UOT to examine treatment dose and efficacy is supported.

Department

Psychiatry and Behavioral Sciences

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