Pediatric Myelodysplastic Syndrome: Updated Classifications and Current Diagnosis and Treatment Challenges

Authors

Zaina Inam, From the Center for Cancer and Blood Disorders, Children's National Hospital, Washington, DC (Inam, Diab, Schore, Vatsayan, Cheng).
Miao Pan, From the Center for the Divisions of Pathology and Laboratory Medicine, Children's National Hospital, Washington, DC (Pan, Cheng).
Yaser Diab, From the Center for Hematology, Children's National Hospital, Washington, DC (Diab).
Reuven Schore, From the Center for Oncology, Children's National Hospital, Washington, DC (Schore).
Anant Vatsayan, From the Center for Blood and Marrow Transplantation, Children's National Hospital, Washington, DC (Vatsayan).
Jinjun Cheng, From the Center for Cancer and Blood Disorders, Children's National Hospital, Washington, DC (Inam, Diab, Schore, Vatsayan, Cheng).

Document Type

Journal Article

Publication Date

7-1-2025

Journal

Archives of pathology & laboratory medicine

Volume

149

Issue

7

DOI

10.5858/arpa.2024-0164-RA

Abstract

CONTEXT.—: Myelodysplastic syndromes (MDSs) are rare in children and have unique clinical manifestations and implications. OBJECTIVE.—: To review the clinical features, pathogenesis, and classification of pediatric MDS. DATA SOURCES.—: Published literature and personal experience. CONCLUSIONS.—: Pediatric MDS vastly differs from adult MDS. Evaluation for the presence of an underlying germline predisposition syndrome is critical for optimal classification and management. Because of the rarity of cases, resources to aid with the recognition, diagnosis, and management of pediatric MDS are limited, and multi-institutional collaborative studies are needed for the future.

APA Citation

Inam, Zaina; Pan, Miao; Diab, Yaser; Schore, Reuven; Vatsayan, Anant; and Cheng, Jinjun, "Pediatric Myelodysplastic Syndrome: Updated Classifications and Current Diagnosis and Treatment Challenges" (2025). GW Authored Works. Paper 7689.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/7689

Department

Pediatrics