Bioactive lipid profiles as non-invasive biomarkers of advanced fibrosis in people with HIV/HCV co-infection

Authors

Tzu-Hao Lee, Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, 6620 Main Street, Suite 1450, Houston, TX, 77030, USA. Howard.Lee@bcm.edu.
Kara Wegermann, Division of Gastroenterology, Department of Medicine, Duke University Health System, Durham, NC, USA.
Rachel Safeek, Department of Surgery, University of Florida, Gainesville, FL, USA.
Meredith Mock, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Sam Lusk, Duke Clinical Research Institute, Durham, NC, USA.
Lisa St John-Williams, Duke Center for Genomic and Computational Biology, Durham, NC, USA.
Will J. Thompson, Duke Center for Genomic and Computational Biology, Durham, NC, USA.
Joseph E. Lucas, Vital Statistics LLC, Chapel Hill, USA.
M Arthur Moseley, Duke Center for Genomic and Computational Biology, Durham, NC, USA.
Keyur Patel, Division of Gastroenterology and Hepatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Susanna Naggie, Division of Infectious Diseases, Department of Medicine, Duke University Health System, Durham, NC, USA.

Document Type

Journal Article

Publication Date

7-1-2025

Journal

Metabolomics : Official journal of the Metabolomic Society

Volume

21

Issue

4

DOI

10.1007/s11306-025-02293-5

Keywords

Coinfecton; Eicosanoid; Fibrosis; HIV; Hepatitis C virus; Metabolite; Metabolomics; Oxylipin

Abstract

Non-invasive assessments for advanced liver fibrosis have limited accuracy in persons with human immunodeficiency virus (HIV) (PWH) who have hepatitis C virus (HCV) co-infection, and new tools are needed. Our aim was to discover oxylipin profiles associated with advanced liver fibrosis in treatment-naïve patients with HIV/HCV co-infection. Serum samples from 40 PWH with HCV were subjected to targeted oxylipin analysis. A model with AST and seven metabolites, including 5(S)-HEPE, 8-HETE, 14,15-DiHETrE, 4-HDoHE, 14- HDoHE, 7-HDoHE, and 9,10-DiHOME yielded an area under the receiver operating characteristic curve of 0.93, with optimal sensitivity and specificity of 86% and 88%, respectively.

APA Citation

Lee, Tzu-Hao; Wegermann, Kara; Safeek, Rachel; Mock, Meredith; Lusk, Sam; John-Williams, Lisa St; Thompson, Will J.; Lucas, Joseph E.; Moseley, M Arthur; Patel, Keyur; and Naggie, Susanna, "Bioactive lipid profiles as non-invasive biomarkers of advanced fibrosis in people with HIV/HCV co-infection" (2025). GW Authored Works. Paper 7676.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/7676

Department

Physician Assistant Studies