Insulin Dependency Rather Than HbA1c May Be a Hallmark for Worse 30-Day Complications for Diabetes Mellitus Patients with Chronic Limb-Threatening Ischemia Undergoing Infrainguinal Bypass

Document Type

Journal Article

Publication Date

7-8-2025

Journal

Annals of vascular surgery

Volume

121

DOI

10.1016/j.avsg.2025.06.041

Abstract

BACKGROUND: The relationship between insulin use and clinical outcomes in patients with chronic-limb threatening ischemia remains unclear. This study evaluates differences between patients with diabetes mellitus (DM) stratified by insulin use, revealing potential outcome disparities following bypass procedures. METHODS: Thirty-day outcome data was collected retrospectively from a cohort of chronic-limb threatening ischemia patients with DM following bypass procedures between 2011 and 2022 using the American College of Surgeons National Surgical Quality Improvement Program. Participants were divided into 2 groups based on insulin use. Multivariable analysis controlled for confounders and compared 30-day outcomes. A separate analysis without controlling for hemoglobin A1c (HbA1c) was conducted to examine its impact. RESULTS: Eight hundred fifty-eight patients were included. Mortality was similar between insulin users and noninsulin users (2.66% vs. 2.11%, adjusted odds ratios (aORs) 0.73, 95% confidence interval (CI) 0.27-1.97, P = 0.66), as were amputation rates (3.61% vs. 3.92%, aOR 0.84, 95% CI 0.38-1.89, P = 0.85). Renal complications occurred more frequently in insulin users compared to noninsulin users (7.60% vs. 3.31%, aOR 2.67, 95% CI 1.27-5.60, P = 0.01). Other complications, including major adverse limb events, major adverse cardiovascular events, sepsis, and bleeding requiring transfusion were more common in insulin users but were not statistically significant. Outcomes remained consistent regardless of HbA1c adjustment. CONCLUSION: Insulin dependency, rather than HbA1c, is a hallmark for worse 30-day complications for DM patients undergoing bypass, with a significantly increased rate of renal complications and a nonsignificant trend toward higher bleeding requiring transfusion. This underscores the need to identify other modifiable factors influencing outcomes in insulin-dependent patients.

Department

School of Medicine and Health Sciences Student Works

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