Addressing conceptual and design gaps in the oncology nutrition evidence base during chemotherapy: contributions of the Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes Consortium

Authors

Stephanie L. Compton, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Heather Wopat, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Melissa Lopez-Pentecost, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Tanya Agurs-Collins, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.
Justin C. Brown, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Bette Caan, Kaiser Permanente of Northern California, Oakland, CA, USA.
Wendy Demark-Wahnefried, University of Alabama at Birmingham, Birmingham, AL, USA.
Joanne W. Elena, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.
Leah M. Ferrucci, Yale Cancer Center, Yale University, New Haven, CT, USA.
Courtney McGowan, Yale School of Public Health, Yale University, New Haven, CT, USA.
Leah S. Puklin, Yale School of Public Health, Yale University, New Haven, CT, USA.
Kathryn H. Schmitz, University of Pittsburgh, Hillman Cancer Center, Pittsburgh, PA, USA.
Cynthia A. Thomson, Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Kim Robien, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Tracy E. Crane, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.

Document Type

Journal Article

Publication Date

7-18-2025

Journal

Journal of the National Cancer Institute

DOI

10.1093/jnci/djaf143

Abstract

Evidence to support the development of practice guidelines on nutrition interventions during active cancer treatment is limited despite the established role of nutrition in cancer prevention and long-term survivorship. To address this gap, the National Cancer Institute (NCI) funded the Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes (ENICTO) research consortium. This manuscript focuses on the nutrition-specific work within the ENICTO Consortium. We present a conceptual framework describing how nutritional interventions may enhance cancer treatment tolerance and timely completion of chemotherapy. We also describe how each ENICTO research project selected specific nutrition-related data items and collection methods to test hypotheses outlined in the conceptual framework. Research and consortium-wide projects are described in relation to advancing the scientific rigor of research in the field, including the standardization of nutrition assessment tools and measures. We conclude with a call to action for further research to support the development of evidence-based oncology nutrition practice guidelines relevant to the treatment period within the cancer continuum.

APA Citation

Compton, Stephanie L.; Wopat, Heather; Lopez-Pentecost, Melissa; Agurs-Collins, Tanya; Brown, Justin C.; Caan, Bette; Demark-Wahnefried, Wendy; Elena, Joanne W.; Ferrucci, Leah M.; McGowan, Courtney; Puklin, Leah S.; Schmitz, Kathryn H.; Thomson, Cynthia A.; Robien, Kim; and Crane, Tracy E., "Addressing conceptual and design gaps in the oncology nutrition evidence base during chemotherapy: contributions of the Exercise and Nutrition Interventions to Improve Cancer Treatment-Related Outcomes Consortium" (2025). GW Authored Works. Paper 7568.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/7568

Department

Exercise and Nutrition Sciences