Comparison of quality of life outcomes in a de-intensification treatment regimen for p16 + oropharyngeal cancer

Esther Lee, Division of Otolaryngology-Head and Neck Surgery, George Washington University School of Medicine and Health Sciences, 2300 M Street, NW, 4th Floor, Washington, DC, 20037, USA. esther.lee1@westernu.edu.
Hannah R. Crowder, Division of Otolaryngology-Head and Neck Surgery, George Washington University School of Medicine and Health Sciences, 2300 M Street, NW, 4th Floor, Washington, DC, 20037, USA.
Daniel Gorelik, Division of Otolaryngology-Head and Neck Surgery, George Washington University School of Medicine and Health Sciences, 2300 M Street, NW, 4th Floor, Washington, DC, 20037, USA.
Christopher Badger, Division of Otolaryngology-Head and Neck Surgery, George Washington University School of Medicine and Health Sciences, 2300 M Street, NW, 4th Floor, Washington, DC, 20037, USA.
Jennifer Schottler, Division of Otolaryngology-Head and Neck Surgery, George Washington University School of Medicine and Health Sciences, 2300 M Street, NW, 4th Floor, Washington, DC, 20037, USA.
Ning-Wei Li, Division of Otolaryngology-Head and Neck Surgery, George Washington University School of Medicine and Health Sciences, 2300 M Street, NW, 4th Floor, Washington, DC, 20037, USA.
Robert Siegel, Division of Hematology and Oncology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Nader Sadeghi, Department of Otolaryngology-Head and Neck Surgery, McGill University Health Center, McGill University, Montreal, QC, Canada.
Punam G. Thakkar, Division of Otolaryngology-Head and Neck Surgery, George Washington University School of Medicine and Health Sciences, 2300 M Street, NW, 4th Floor, Washington, DC, 20037, USA.
Arjun S. Joshi, Division of Otolaryngology-Head and Neck Surgery, George Washington University School of Medicine and Health Sciences, 2300 M Street, NW, 4th Floor, Washington, DC, 20037, USA.
Joseph F. Goodman, Division of Otolaryngology-Head and Neck Surgery, George Washington University School of Medicine and Health Sciences, 2300 M Street, NW, 4th Floor, Washington, DC, 20037, USA.

Document Type

Journal Article

Publication Date

4-23-2022

Journal

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

DOI

10.1007/s00405-022-07387-7

Keywords

Neoadjuvant chemotherapy; Oropharyngeal squamous cell carcinoma; Quality of life; Swallowing; Transoral robotic surgery; University of Washington Quality of Life (UW-QOL)

Abstract

BACKGROUND: Platinum and taxane-based neoadjuvant chemotherapy with surgery (NAC + S) is a novel de-intensified treatment modality that is currently under investigation. METHODS: All patients treated for HPV positive OPSCC with NAC + S at a single institution between 2006 and 2020 were contacted to complete the University of Washington Quality of life questionnaire (UW-QOL) at least 2 years following the completion of treatment. RESULTS: The UW-QOL surveys were received from 25 of 48 eligible patients (52.1%). The mean follow-up time was 4.3 years (range 2.0-7.6 years). The overall mean score for the physical subscale was 92.4 (Standard deviation, SD = 10.9), and the social-emotional subscale was 91.1 (11.8). Compared to the normative cohort, the NAC + S cohort had a worse appearance (Mean scores Normative vs. NAC + S: 93 vs. 84.0, p = 0.009). CONCLUSION: NAC + S offers favorable long-term QOL, as evidenced by near-normal scores in most QOL domains.

Department

Medicine

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