Plasma Proteomic Biomarkers in Alzheimer's Disease and Cardiovascular Disease: A Longitudinal Study

Authors

Laurie A. Theeke, Department of Community of Acute and Chronic Care, School of Nursing, The George Washington University, Ashburn, VA 20147, USA.
Ying Liu, Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN 37614, USA.
Silas Wang, Department of Statistics & Data Science, Dietrich College of Humanities and Social Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Xingguang Luo, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA.
R Osvaldo Navia, Department of Medicine and Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV 26506, USA.
Danqing Xiao, Department of STEM, School of Arts and Sciences, Regis College, Weston, MA 02493, USA.
Chun Xu, Department of Health and Biomedical Sciences, College of Health Affairs, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA.
Kesheng Wang, Department of Biobehavioral Health & Nursing Science, College of Nursing, University of South Carolina, Columbia, 1601 Greene Street, Columbia, SC 29208, USA.
The Alzheimer And Disease Neuroimaging Initiative

Document Type

Journal Article

Publication Date

10-6-2024

Journal

International journal of molecular sciences

Volume

25

Issue

19

DOI

10.3390/ijms251910751

Keywords

APOE-ε4; Alzheimer’s disease; biomarkers; cardiovascular diseases; linear mixed model; mild cognitive impairment; proteomics

Abstract

The co-occurrence of Alzheimer's disease (AD) and cardiovascular diseases (CVDs) in older adults highlights the necessity for the exploration of potential shared risk factors. A total of 566 adults were selected from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, including 111 individuals with AD, 383 with mild cognitive impairment (MCI), and 410 with CVD. The multivariable linear mixed model (LMM) was used to investigate the associations of AD and CVD with longitudinal changes in 146 plasma proteomic biomarkers (measured at baseline and the 12-month follow-up). The LMM showed that 48 biomarkers were linked to AD and 46 to CVD (p < 0.05). Both AD and CVD were associated with longitudinal changes in 14 biomarkers (α1Micro, ApoH, β2M, BNP, complement C3, cystatin C, KIM1, NGAL, PPP, TIM1, THP, TFF3, TM, and VEGF), and both MCI and CVD were associated with 12 biomarkers (ApoD, AXL, BNP, Calcitonin, CD40, C-peptide, pM, PPP, THP, TNFR2, TTR, and VEGF), suggesting intricate connections between cognitive decline and cardiovascular health. Among these, the Tamm Horsfall Protein (THP) was associated with AD, MCI, CVD, and APOE-ε4. This study provides valuable insights into shared and distinct biological markers and mechanisms underlying AD and CVD.

APA Citation

Theeke, Laurie A.; Liu, Ying; Wang, Silas; Luo, Xingguang; Navia, R Osvaldo; Xiao, Danqing; Xu, Chun; Wang, Kesheng; and The Alzheimer And Disease Neuroimaging Initiative, "Plasma Proteomic Biomarkers in Alzheimer's Disease and Cardiovascular Disease: A Longitudinal Study" (2024). GW Authored Works. Paper 5866.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/5866

Department

Nursing Faculty Publications