Standardizing Retrospective Observational Research in Cutaneous Squamous Cell Carcinoma: Expert Panel Guidelines from ITSCC

Shayan Cheraghlou, The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York.
Mary L. Stevenson, The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York.
Sean R. Christensen, Department of Dermatology, Yale School of Medicine, New Haven, Connecticut.
Jeremy S. Bordeaux, Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Joanna L. Walker, Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia.
Divya Srivastava, Department of Dermatology, University of Texas Southwestern Medical Center, Dallas.
Carla Ferrándiz-Pulido, Department of Dermatology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Kristin P. Bibee, Departments of Dermatology and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Joi B. Carter, Department of Dermatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire.
Faramarz H. Samie, Department of Dermatology, Columbia University Irving Medical Center, New York, New York.
Vishal A. Patel, Department of Dermatology, The George Washington University School of Medicine & Health Sciences, Washington, DC.
Bryan T. Carroll, Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Allison T. Vidimos, Department of Dermatology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio.
Christian L. Baum, Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
Justin J. Leitenberger, Department of Dermatology, Oregon Health & Science University, Portland.
Anokhi Jambusaria-Pahlajani, Division of Dermatology, Department of Internal Medicine, Dell Medical School at the University of Texas at Austin, Austin.
Emily S. Ruiz, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
John A. Carucci, The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York.
David R. Carr, Department of Dermatology, The Ohio State University Wexner Medical Center, Columbus.
Kathryn T. Shahwan, Department of Dermatology, The Ohio State University Wexner Medical Center, Columbus.

Document Type

Journal Article

Publication Date

9-1-2024

Journal

JAMA dermatology

Volume

160

Issue

9

DOI

10.1001/jamadermatol.2024.2242

Abstract

IMPORTANCE: Cutaneous squamous cell carcinoma (CSCC) is the second most common malignant disease in the US. Although it typically carries a good prognosis, a subset of CSCCs are highly aggressive, carrying regional and distant metastatic potential. Due to its high incidence, this aggressive subset is responsible for considerable mortality, with an overall annual mortality estimated to equal or even surpass melanoma. Despite this morbidity, CSCC is excluded from national cancer registries, making it difficult to study its epidemiology and outcomes. Therefore, the bulk of the CSCC literature is composed of single-center and multi-institutional retrospective cohort analyses. Given variations in reporting measures and analyses in these studies, interpretability between studies and the ability to pool results are limited. OBJECTIVE: To define standardized reporting measures for retrospective CSCC studies. FINDINGS: An expert panel was convened to determine standardized guidelines for recording and analyzing retrospective CSCC data. A total of 13 dermatologists and dermatologic surgeons with more than 5 years of posttraining experience and considerable experience with performing CSCC outcomes research were recruited to the panel. Consensus recommendations were achieved for CSCC retrospective study reporting measures, definitions, and analyses. CONCLUSIONS AND RELEVANCE: The recommendations in this report present the potential to standardize future CSCC retrospective studies. With such standardization, future work may have greater interstudy interpretability and allow for pooled analyses.

Department

Dermatology

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