Tricuspid Annular Plane Systolic Excursion (TAPSE) in COPD Patients, A Systematic Review and Meta-Analysis

Authors

M Groussis, Department of Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Q K. Tran, Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.
M Hoffer, Department of Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
J Ahari, Pulmonary and Critical Care Medicine, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, United States.
A Pourmand, Department of Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, United States.

Document Type

Journal Article

Publication Date

9-6-2024

Journal

Clinical and experimental emergency medicine

DOI

10.15441/ceem.24.228

Keywords

COPD; TAPSE; Tricuspid annular plane systolic excursion

Abstract

INTRODUCTION: Tricuspid annular plane systolic excursion (TAPSE) is an echocardiographic parameter that serves as a prognostic indicator for severity of COPD clinical course. This study, consisting of a systematic review and meta-analysis, evaluates the current literature to elucidate the relationship between TAPSE measurement in COPD patients versus control subjects to discern baseline evidence of right heart strain. METHODS: PubMedTM, ScopusTM, CINAHL, Web of Science, and Cochrane Review databases were searched from their beginning through November 1, 2023, for eligible studies. Outcomes included the difference of TAPSE measurement and right ventricular wall thickness between COPD patients and control patients. The Newcastle-Ottawa Scale was applied to assess risk of bias; Q-statistics and I2 values were used to assess for heterogeneity; and Egger's and Begg's test used to assess for publication bias. RESULTS: The search yielded eleven studies reporting TAPSE values involving 1671 patients, 800 (47.9%) patients with COPD. The unadjusted mean TAPSE values for COPD patients was 18.9 mm (SD+/- 4), while the mean TAPSE value for control patients was 22.2 mm (SD+/- 0.8). The presence of COPD was significantly associated with decreased TAPSE values with the meta-analysis reporting the mean difference of TAPSE value between COPD and control patients was -3.0 (95% CI -4.3 to -1.7, P=0.001). Six studies reported the RV free wall thickness. The unadjusted mean RV free wall thickness for COPD patients was 4.9 mm (SD+/- 1.2), and control patients was 3.4 mm (SD+/- 0.7), respectively. CONCLUSIONS: This meta-analysis demonstrated statistically-significantly lower TAPSE values and thicker RV free wall among COPD patients versus control patients.

APA Citation

Groussis, M; Tran, Q K.; Hoffer, M; Ahari, J; and Pourmand, A, "Tricuspid Annular Plane Systolic Excursion (TAPSE) in COPD Patients, A Systematic Review and Meta-Analysis" (2024). GW Authored Works. Paper 5674.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/5674

Department

Emergency Medicine