Monoaminergic Modulation of Learning and Cognitive Function in the Prefrontal Cortex

Authors

Natalie Boyle, Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.
Sarah Betts, Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.
Hui Lu, Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.

Document Type

Journal Article

Publication Date

9-6-2024

Journal

Brain sciences

Volume

14

Issue

9

DOI

10.3390/brainsci14090902

Keywords

cognition; dopamine; learning; monoamines; norepinephrine; prefrontal cortex; serotonin

Abstract

Extensive research has shed light on the cellular and functional underpinnings of higher cognition as influenced by the prefrontal cortex. Neurotransmitters act as key regulatory molecules within the PFC to assist with synchronizing cognitive state and arousal levels. The monoamine family of neurotransmitters, including dopamine, serotonin, and norepinephrine, play multifaceted roles in the cognitive processes behind learning and memory. The present review explores the organization and signaling patterns of monoamines within the PFC, as well as elucidates the numerous roles played by monoamines in learning and higher cognitive function.

APA Citation

Boyle, Natalie; Betts, Sarah; and Lu, Hui, "Monoaminergic Modulation of Learning and Cognitive Function in the Prefrontal Cortex" (2024). GW Authored Works. Paper 5665.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/5665

Department

Pharmacology and Physiology