Endocrine Disruptors in Pregnancy: Effects on Mothers and Fetuses-A Review

Document Type

Journal Article

Publication Date

9-19-2024

Journal

Journal of clinical medicine

Volume

13

Issue

18

DOI

10.3390/jcm13185549

Keywords

bisphenol A; endocrine disruptors; environmental exposure; fetal development; fluorocarbons; organophosphates; phthalic acids; pregnancy

Abstract

: Endocrine disruptors are ubiquitous agents in the environment and are present in everyday consumer products. These agents can interfere with the endocrine system, and subsequently the reproductive system, especially in pregnancy. An increasing number of studies have been conducted to discover and describe the health effects of these agents on humans, including pregnant women, their fetuses, and the placenta. This review discusses prenatal exposure to various endocrine disruptors, focusing on bisphenols, phthalates, organophosphates, and perfluoroalkyl substances, and their effects on pregnancy and fetal development. : We reviewed the literature via the PubMed and EBSCO databases and included the most relevant studies. : Our findings revealed that several negative health outcomes were linked to endocrine disruptors. However, despite the seriousness of this topic and the abundance of research on these agents, it remains challenging to draw strong conclusions about their effects from the available studies. This does not allow for strong, universal guidelines and might result in poor patient counseling and heterogeneous approaches to regulating endocrine disruptors. : The seriousness of this matter calls for urgent efforts, and more studies are needed in this realm, to protect pregnant patients, and ultimately, in the long term, society.

Department

Obstetrics and Gynecology

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