Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol

Douglas C. Dean, Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: deaniii@wisc.edu.
M Dylan Tisdall, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jessica L. Wisnowski, Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Department of Radiology, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Eric Feczko, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
Borjan Gagoski, Department of Radiology, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.
Andrew L. Alexander, Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
Richard A. Edden, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Wei Gao, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Timothy J. Hendrickson, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA.
Brittany R. Howell, Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA; Department of Human Development and Family Science, Virginia Tech, Blacksburg, VA, USA.
Hao Huang, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kathryn L. Humphreys, Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.
Tracy Riggins, Department of Psychology, University of Maryland, College Park, MD, USA.
Chad M. Sylvester, Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA; Taylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis, St. Louis, MO, USA.
Kimberly B. Weldon, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
Essa Yacoub, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
Banu Ahtam, Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Natacha Beck, McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.
Suchandrima Banerjee, GE HealthCare, Menlo Park, CA, USA.
Sergiy Boroday, McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.
Arvind Caprihan, The Mind Research Network, Albuquerque, NM, USA.
Bryan Caron, McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.
Samuel Carpenter, Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA.
Yulin Chang, Siemens Medical Solutions USA Inc, PA, USA.
Ai Wern Chung, Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Matthew Cieslak, Penn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
William T. Clarke, Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Anders Dale, Department of Radiology, University of California San Diego, La Jolla, CA, USA; Multimodal Imaging Laboratory, University of California San Diego, La Jolla, CA, USA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Samir Das, McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.
Christopher W. Davies-Jenkins, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Alexander J. Dufford, Department of Psychiatry and Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, USA.
Alan C. Evans, McGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.

Document Type

Journal Article

Publication Date

9-21-2024

Journal

Developmental cognitive neuroscience

Volume

70

DOI

10.1016/j.dcn.2024.101452

Keywords

Development; HBCD; Infant; MRI; MRS; Protocol

Abstract

The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The acquisition of multimodal magnetic resonance-based brain development data is central to the study's core protocol. However, application of Magnetic Resonance Imaging (MRI) methods in this population is complicated by technical challenges and difficulties of imaging in early life. Overcoming these challenges requires an innovative and harmonized approach, combining age-appropriate acquisition protocols together with specialized pediatric neuroimaging strategies. The HBCD MRI Working Group aimed to establish a core acquisition protocol for all 27 HBCD Study recruitment sites to measure brain structure, function, microstructure, and metabolites. Acquisition parameters of individual modalities have been matched across MRI scanner platforms for harmonized acquisitions and state-of-the-art technologies are employed to enable faster and motion-robust imaging. Here, we provide an overview of the HBCD MRI protocol, including decisions of individual modalities and preliminary data. The result will be an unparalleled resource for examining early neurodevelopment which enables the larger scientific community to assess normative trajectories from birth through childhood and to examine the genetic, biological, and environmental factors that help shape the developing brain.

Department

Radiology

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