The effect of oral clonidine and intravenous dexmedetomidine administration on the quality of functional endoscopic sinus surgery

Authors

Shahram Samadi, Associate Professor, Anesthesia critical care and pain management research center, Tehran University of Medical Sciences, Tehran, Iran.
Zahra Ghahremaniyeh, Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Shima Khanahmadi, Department of Anesthesiology, Urmia University of Medical Sciences, Urmia, Iran.
Somayeh Ghavipanjeh Rezaiy, Department of Nursing, School of nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran.
Shalaleh Bagheri, Department of Anesthesiology, Urmia University of Medical Sciences, Urmia, Iran.
Ajay Prakash Pasupulla, Professor, Oral and Maxillofacial Pathology, School of Medicine, College of Health Sciences, Wachemo University, Hosanna, Ethiopia.
Shayan Khalilollah, Associate Professor, Anesthesia critical care and pain management research center, Tehran University of Medical Sciences, Tehran, Iran.
Marius Fassbinder, Assistant Professor, Department of Anesthesiology and Critical Care Medicine, George Washington University, USA.
Behzad Kazemi Haki, Department of Anesthesiology, Urmia University of Medical Sciences, Urmia, Iran.
Shahriar Khanahmadi, Department of Anesthesiology, Urmia University of Medical Sciences, Urmia, Iran.
Saghar Mohtashami, University of California Los Angeles, School of Dentistry, Los Angeles, California, USA.

Document Type

Journal Article

Publication Date

9-23-2024

Journal

Journal of perioperative practice

DOI

10.1177/17504589241268620

Keywords

Bleeding; Clonidine and dexmedetomidine; Functional endoscopic sinus surgery; Surgeon satisfaction; Surgical field

Abstract

BACKGROUND: Clonidine and dexmedetomidine are alpha-2 receptor blockers administered for haemorrhage control during surgery in limited settings. Functional endoscopic sinus surgery (FESS) may be associated with bleeding, thus making it challenging. This study aims to evaluate the effect of dexmedetomidine and clonidine on haemorrhage control during FESS and surgical outcomes. METHODS: This three-blinded prospective study included 102 patients who underwent FESS at the Imam Khomeini public referral hospital at the Imam Khomeini public referral hospital, in Urmia, Iran. It was either American Society of Anaesthesiologists (ASA) class I or II. They were divided into three groups (clonidine, dexmedetomidine, and placebo). The volume of blood loss, mean arterial pressure, surgical field visualisation, and surgeon satisfaction were assessed in the three groups. Data analysis was performed using SPSS version 23.0. RESULTS: Dexmedetomidine and clonidine decreased mean arterial pressure, heart rate, and blood loss volume while improving surgical field visualisation. The effect of dexmedetomidine was associated significantly statistically with surgeon satisfaction (p < 0.0001). Furthermore, dexmedetomidine improved the surgical field and reduced operating times in the dexmedetomidine group (p < 0.0001). CONCLUSION: The present clinical trial findings indicated that the administration of dexmedetomidine during FESS decreased mean arterial pressure, provided balanced anaesthesia and appropriate analgesia, and improved the visibility of the surgical field and increased surgeon satisfaction.

APA Citation

Samadi, Shahram; Ghahremaniyeh, Zahra; Khanahmadi, Shima; Ghavipanjeh Rezaiy, Somayeh; Bagheri, Shalaleh; Prakash Pasupulla, Ajay; Khalilollah, Shayan; Fassbinder, Marius; Kazemi Haki, Behzad; Khanahmadi, Shahriar; and Mohtashami, Saghar, "The effect of oral clonidine and intravenous dexmedetomidine administration on the quality of functional endoscopic sinus surgery" (2024). GW Authored Works. Paper 5602.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/5602

Department

Anesthesiology and Critical Care Medicine