Title

Outcomes of Dual Versus Triple Antiretroviral Drug Regimens Among Virally Suppressed Adults in the DC Cohort

Document Type

Journal Article

Publication Date

3-23-2022

Journal

AIDS research and human retroviruses

DOI

10.1089/aid.2021.0202

Keywords

HIV; antiretroviral therapy; dual therapy; regimen simplification; two-drug regimen

Abstract

This study explored virological outcomes of two-drug (2DRs) and three-drug (3DRs) antiretroviral regimens in adults with HIV in the DC Cohort. We analyzed 310 treatment-experienced adults with sustained HIV RNA ≤50 copies/mL at baseline, 53 of whom switched to 2DRs and 257 continued 3DRs. Adults on 2DRs and 3DRs had similar demographics (median age 53.3 years, 76.8% cisgender male, 76.1% Black). Adults on 2DRs had more participants with ≥2 comorbidities (62.3% vs. 42.8%,  = .019), had a longer time since HIV diagnosis (median years 20.4 vs. 13.2,  = .017), and received the regimen of interest for a shorter duration (median years 1.3 vs. 3.3,  < .001) compared with adults on 3DRs. Adults receiving 2DRs had a higher, although nonsignificant, risk for virological failure (two consecutive HIV RNA ≥50 copies/mL) at 24 months follow-up than adults on 3DRs (6.7% vs. 1.7%, respectively;  = .10). Future analysis of the effectiveness of 2DRs is needed.

Department

Pediatrics

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