Outcomes of Dual Versus Triple Antiretroviral Drug Regimens Among Virally Suppressed Adults in the DC Cohort

Authors

Wei Li Koay, Division of Infectious Diseases, Children's National Hospital, Washington, District of Columbia, USA.
Jiayang Xiao, Department of Biostatistics and Bioinformatics and Milken Institute School of Public Health, The George Washington University, Washington, District of Columbia, USA.
Marinella Temprosa, Department of Biostatistics and Bioinformatics and Milken Institute School of Public Health, The George Washington University, Washington, District of Columbia, USA.
Lindsey P. Happ, Department of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, District of Columbia, USA.
Anne K. Monroe, Department of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, District of Columbia, USA.
Amanda D. Castel, Department of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, District of Columbia, USA.
Natella Y. Rakhmanina, Division of Infectious Diseases, Children's National Hospital, Washington, District of Columbia, USA.

Document Type

Journal Article

Publication Date

3-23-2022

Journal

AIDS research and human retroviruses

DOI

10.1089/aid.2021.0202

Keywords

HIV; antiretroviral therapy; dual therapy; regimen simplification; two-drug regimen

Abstract

This study explored virological outcomes of two-drug (2DRs) and three-drug (3DRs) antiretroviral regimens in adults with HIV in the DC Cohort. We analyzed 310 treatment-experienced adults with sustained HIV RNA ≤50 copies/mL at baseline, 53 of whom switched to 2DRs and 257 continued 3DRs. Adults on 2DRs and 3DRs had similar demographics (median age 53.3 years, 76.8% cisgender male, 76.1% Black). Adults on 2DRs had more participants with ≥2 comorbidities (62.3% vs. 42.8%,  = .019), had a longer time since HIV diagnosis (median years 20.4 vs. 13.2,  = .017), and received the regimen of interest for a shorter duration (median years 1.3 vs. 3.3,  < .001) compared with adults on 3DRs. Adults receiving 2DRs had a higher, although nonsignificant, risk for virological failure (two consecutive HIV RNA ≥50 copies/mL) at 24 months follow-up than adults on 3DRs (6.7% vs. 1.7%, respectively;  = .10). Future analysis of the effectiveness of 2DRs is needed.

APA Citation

Koay, Wei Li; Xiao, Jiayang; Temprosa, Marinella; Happ, Lindsey P.; Monroe, Anne K.; Castel, Amanda D.; and Rakhmanina, Natella Y., "Outcomes of Dual Versus Triple Antiretroviral Drug Regimens Among Virally Suppressed Adults in the DC Cohort" (2022). GW Authored Works. Paper 550.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/550

Department

Pediatrics