Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2

Neslihan Pakize Taşlı, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Zeynep Burçin Gönen, Oral and Maxillofacial Surgery, Genome and Stem Cell Centre, Erciyes University, Kayseri, Turkey.
Oğuz Kaan Kırbaş, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Nur Seda Gökdemir, Oral and Maxillofacial Surgery, Genome and Stem Cell Centre, Erciyes University, Kayseri, Turkey.
Batuhan Turhan Bozkurt, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Buse Bayrakcı, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Derya Sağraç, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Ezgi Taşkan, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Sevda Demir, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Nur Ekimci Gürcan, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
Melike Bayındır Bilgiç, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
Ömer Faruk Bayrak, Faculty of Medicine, Yeditepe University, Istanbul, Turkey.
Hazel Yetişkin, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Büşra Kaplan, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Shaikh Terkıs Pavel, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Gökçen Dinç, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Müge Serhatlı, The Scientific and Technological Research Council of Turkey (TÜBITAK) Marmara Research Centre Energy Institute, Kocaeli, Turkey.
Gamze Çakırca, The Scientific and Technological Research Council of Turkey (TÜBITAK) Marmara Research Centre Energy Institute, Kocaeli, Turkey.
Ahmet Eken, Department of Biology, Faculty of Science, Erciyes University, Kayseri, Turkey.
Vedat Aslan, Antalya Training and Research Hospital, Antalya, Turkey.
Mehmet Yay, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Musa Karakukcu, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Ekrem Unal, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Fethi Gül, Department of Anesthesiology and Reanimation, School of Medicine, Marmara University, Istanbul, Turkey.
Kemal Erdem Basaran, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Yusuf Ozkul, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Fikrettin Şahin, Faculty of Engineering, Yeditepe University, Istanbul, Turkey.
Olcay Y. Jones, Division of Rheumatology, Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, United States.
Şaban Tekin, The Scientific and Technological Research Council of Turkey (TÜBITAK) Marmara Research Centre Energy Institute, Kocaeli, Turkey.
Aykut Özdarendeli, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Mustafa Cetin, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

Document Type

Journal Article

Publication Date

1-1-2022

Journal

Frontiers in immunology

Volume

13

DOI

10.3389/fimmu.2022.824378

Keywords

COVID-19; SARS-CoV-2; convalescence plasma; exosome; extracellular vehicles (EVs); viral treatment

Abstract

The scale of the COVID-19 pandemic forced urgent measures for the development of new therapeutics. One of these strategies is the use of convalescent plasma (CP) as a conventional source for passive immunity. Recently, there has been interest in CP-derived exosomes. In this report, we present a structural, biochemical, and biological characterization of our proprietary product, convalescent human immune plasma-derived exosome (ChipEXO), following the guidelines set forth by the Turkish Ministry of Health and the Turkish Red Crescent, the Good Manufacturing Practice, the International Society for Extracellular Vesicles, and the Gene Ontology Consortium. The data support the safety and efficacy of this product against SARS-CoV-2 infections in preclinical models.

Department

Medicine

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