Intraocular Pressure Response in the Untreated Contralateral Eye After Selective Laser Trabeculoplasty

Authors

Jason Dossantos, Department of Ophthalmology, George Washington University School of Medicine and Health Sciences, Washington, USA.
Tyler Muser, Department of Ophthalmology, George Washington University School of Medicine and Health Sciences, Washington, USA.
Devin Hill, Department of Ophthalmology, George Washington University School of Medicine and Health Sciences, Washington, USA.
Stephen Lesche, Department of Ophthalmology, George Washington University School of Medicine and Health Sciences, Washington, USA.
Aseef Ahmed, Department of Ophthalmology, George Washington University School of Medicine and Health Sciences, Washington, USA.
David Belyea, Department of Ophthalmology, George Washington University School of Medicine and Health Sciences, Washington, USA.

Document Type

Journal Article

Publication Date

8-1-2024

Journal

Cureus

Volume

16

Issue

8

DOI

10.7759/cureus.67537

Keywords

contralateral effect; contralateral eye; glaucoma medication; primary open angle glaucoma; selective laser trabeculoplasty

Abstract

AIM: To examine the impact of selective laser trabeculoplasty (SLT) on intraocular pressure (IOP) in the untreated contralateral eye within 12 months after the procedure. METHODS: A retrospective chart review was conducted on patients with primary open-angle, normal-tension, pigmentary, or pseudoexfoliation glaucoma who received 360-degree SLT at George Washington University. Exclusion criteria included prior or subsequent laser or glaucoma surgery within 12 months of SLT, other glaucoma types, or corticosteroid use during follow-up. Primary outcomes were IOP and medication reduction, and SLT success, defined as reducing IOP by ≥20% without additional IOP-lowering procedures or medications. Follow-up occurred at six weeks, six months, and 12 months. Demographic and clinical data were analyzed using ANOVA, paired t-tests, and chi-squared tests. RESULTS: A total of 125 patients were included, representing a range of backgrounds: African American (57.6%), Caucasian (31.2%), Asian (5.6%), and Hispanic/Latino (4%), and 1.6% did not report their background. Significant reductions in mean IOP and medication numbers were observed in the contralateral eye at six weeks and six months (p<0.05) but not at 12 months. The contralateral eye success rates were 24% at six weeks and six months and 20.8% at 12 months. The contralateral eye was more likely to achieve success if the ipsilateral eye was successful at six weeks (odds ratio (95% confidence interval): 5.05 (1.89-13.48)), six months (16.1 (4.56-57.17)), and 12 months (5.94 (2.07-17.04)) (p<0.001 for all). CONCLUSION: First-time SLT results in statistically significant IOP and medication reductions in the contralateral eye at six weeks and six months. The contralateral eye was 5.05-16.1 times more likely to achieve success if the ipsilateral eye was successful within 12 months.

APA Citation

Dossantos, Jason; Muser, Tyler; Hill, Devin; Lesche, Stephen; Ahmed, Aseef; and Belyea, David, "Intraocular Pressure Response in the Untreated Contralateral Eye After Selective Laser Trabeculoplasty" (2024). GW Authored Works. Paper 5445.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/5445

Department

Ophthalmology