Advances in Spinal Neuromodulation for Chemotherapy-induced Peripheral Neuropathy
Document Type
Journal Article
Publication Date
7-1-2024
Journal
Anticancer research
Volume
44
Issue
7
DOI
10.21873/anticanres.17088
Keywords
Chemotherapy-induced peripheral neuropathy; dorsal root ganglion stimulation; neuromodulation; spinal cord stimulation
Abstract
BACKGROUND/AIM: Chemotherapy-induced peripheral neuropathy (CIPN) continues to be a major source of chronic morbidity in patients with cancer. Current treatment options and efficacy are limited; thus, there is a need to investigate more effective therapeutic options. Spinal neuromodulation including dorsal column spinal cord stimulation (SCS) and dorsal root ganglion stimulation (DRG-S) are being explored for these patients. The purpose of this narrative review was to critically summarize and evaluate the advancements that have been made in utilizing SCS and DRG-S for CIPN. MATERIALS AND METHODS: A thorough literature search was conducted using PubMed for any research on patients with CIPN who underwent DRG-S or SCS. Studies involving patients with general cancer-related pain were not included. Only articles that were published in English, had original, extractable data, and were available on or before August 1, 2023, were included. RESULTS: This study evaluated twelve studies with a total of 13 patients that reported using SCS for CIPN and four studies with a total of 12 patients that reported using DRG-S for CIPN. Many of the studies demonstrated that DRG-S or SCS can assist in reducing opioid consumption, lowering pain scores, and improving sensory deficits. CONCLUSION: DRG-S and SCS have the potential to improve symptoms and lower medication usage in patients suffering from CIPN. Spinal neuromodulation could be considered as an alternative therapy for patients with persistent symptoms.
APA Citation
Gupta, Puneet; Patel, Kunj; and Paul, Geet, "Advances in Spinal Neuromodulation for Chemotherapy-induced Peripheral Neuropathy" (2024). GW Authored Works. Paper 5365.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/5365
Department
Anesthesiology and Critical Care Medicine