Colloid Carcinoma of the Pancreas: A Rare Initial Presentation of Lynch Syndrome

Document Type

Journal Article

Publication Date

7-1-2024

Journal

ACG case reports journal

Volume

11

Issue

7

DOI

10.14309/crj.0000000000001415

Keywords

colloid carcinoma; genetic testing; lynch syndrome; mismatch repair; pancreatic cancer

Abstract

Patients with Lynch syndrome, most commonly associated with colorectal cancer, have an increased risk of developing other tumors including pancreatic ductal adenocarcinoma and precursor lesions, such as intraductal papillary mucinous neoplasms. Here, we present a case of a man in his early 20s who presented with a retroperitoneal mass involving the head of the pancreas. Following a pancreaticoduodenectomy combined with para-aortic lymphadenectomy, a pathologic diagnosis of colloid carcinoma, also known as mucinous noncystic carcinoma, of the pancreas was reported. Further testing established the diagnosis of Lynch syndrome. This case is unique because colloid carcinoma of the pancreas is rare and has never been reported as an initial presentation of Lynch syndrome.

Department

Pathology

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