Chassis-based fiber-coupled optical probe design for reproducible quantitative diffuse optical spectroscopy measurements

Authors

Giselle C. Matlis, Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.
Qihuang Zhang, Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, United States of America.
Emilie J. Benson, Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.
M Katie Weeks, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.
Kristen Andersen, Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.
Jharna Jahnavi, Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.
Alec Lafontant, Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.
Jake Breimann, Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.
Thomas Hallowell, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.
Yuxi Lin, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.
Daniel J. Licht, Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.
Arjun G. Yodh, Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, United States of America.
Todd J. Kilbaugh, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.
Rodrigo M. Forti, Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.
Brian R. White, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States of America.
Wesley B. Baker, Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.
Rui Xiao, Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, United States of America.
Tiffany S. Ko, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.

Document Type

Journal Article

Publication Date

1-1-2024

Journal

PloS one

Volume

19

Issue

7

DOI

10.1371/journal.pone.0305254

Abstract

Advanced optical neuromonitoring of cerebral hemodynamics with hybrid diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) methods holds promise for non-invasive characterization of brain health in critically ill patients. However, the methods' fiber-coupled patient interfaces (probes) are challenging to apply in emergent clinical scenarios that require rapid and reproducible attachment to the head. To address this challenge, we developed a novel chassis-based optical probe design for DOS/DCS measurements and validated its measurement accuracy and reproducibility against conventional, manually held measurements of cerebral hemodynamics in pediatric swine (n = 20). The chassis-based probe design comprises a detachable fiber housing which snaps into a 3D-printed, circumferential chassis piece that is secured to the skin. To validate its reproducibility, eight measurement repetitions of cerebral tissue blood flow index (BFI), oxygen saturation (StO2), and oxy-, deoxy- and total hemoglobin concentration were acquired at the same demarcated measurement location for each pig. The probe was detached after each measurement. Of the eight measurements, four were acquired by placing the probe into a secured chassis, and four were visually aligned and manually held. We compared the absolute value and intra-subject coefficient of variation (CV) of chassis versus manual measurements. No significant differences were observed in either absolute value or CV between chassis and manual measurements (p > 0.05). However, the CV for BFI (mean ± SD: manual, 19.5% ± 9.6; chassis, 19.0% ± 10.8) was significantly higher than StO2 (manual, 5.8% ± 6.7; chassis, 6.6% ± 7.1) regardless of measurement methodology (p<0.001). The chassis-based DOS/DCS probe design facilitated rapid probe attachment/re-attachment and demonstrated comparable accuracy and reproducibility to conventional, manual alignment. In the future, this design may be adapted for clinical applications to allow for non-invasive monitoring of cerebral health during pediatric critical care.

APA Citation

Matlis, Giselle C.; Zhang, Qihuang; Benson, Emilie J.; Weeks, M Katie; Andersen, Kristen; Jahnavi, Jharna; Lafontant, Alec; Breimann, Jake; Hallowell, Thomas; Lin, Yuxi; Licht, Daniel J.; Yodh, Arjun G.; Kilbaugh, Todd J.; Forti, Rodrigo M.; White, Brian R.; Baker, Wesley B.; Xiao, Rui; and Ko, Tiffany S., "Chassis-based fiber-coupled optical probe design for reproducible quantitative diffuse optical spectroscopy measurements" (2024). GW Authored Works. Paper 5229.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/5229

Department

Neurology