Pediatric lymphoproliferative disorders associated with inborn errors of immunity

Authors

Jinjun Cheng, Department of Pathology and Laboratory Medicine, Children's National Hospital, Washington, DC, United States of America; Centers for Cancer & Blood Disorders and Cancer & Immunology Research, Children's National Hospital, Washington, DC, United States of America; The George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America. Electronic address: jcheng2@childrensnational.org.
Blachy J. Dávila Saldaña, Centers for Cancer & Blood Disorders and Cancer & Immunology Research, Children's National Hospital, Washington, DC, United States of America; The George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America.
Shanmuganathan Chandrakasan, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, United States of America.
Michael Keller, Centers for Cancer & Blood Disorders and Cancer & Immunology Research, Children's National Hospital, Washington, DC, United States of America; The George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America.

Document Type

Journal Article

Publication Date

7-26-2024

Journal

Clinical immunology (Orlando, Fla.)

Volume

266

DOI

10.1016/j.clim.2024.110332

Keywords

EBV; Inborn errors of immunity; International consensus classification; Lymphoma; Lymphoproliferative disorder; WHO classification

Abstract

Both non-malignant and malignant lymphoproliferative disorders (LPD) are commonly seen in patients with inborn errors of immunity (IEI), which may be the presenting manifestations or may develop during the IEI disease course. Here we review the clinical, histopathological, and molecular features of benign and malignant LPD associated with IEI and recognize the diagnostic challenges.

APA Citation

Cheng, Jinjun; Dávila Saldaña, Blachy J.; Chandrakasan, Shanmuganathan; and Keller, Michael, "Pediatric lymphoproliferative disorders associated with inborn errors of immunity" (2024). GW Authored Works. Paper 5224.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/5224

Department

Pediatrics