Association of tea and coffee consumption and biliary tract cancer risk: The Biliary Tract Cancers Pooling Project

Yu-Han Huang, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Erikka Loftfield, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Ilona Argirion, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Hans-Olov Adami, Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Demetrius Albanes, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Andrew T. Chan, Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Veronika Fedirko, Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Gary E. Fraser, School of Public Health, Loma Linda University, Loma Linda, California, USA.
Neal D. Freedman, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Graham G. Giles, Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.
Patricia Hartge, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Verena Katzke, Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Synnove F. Knutsen, School of Public Health, Loma Linda University, Loma Linda, California, USA.
James Lacey, Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope, Duarte, California, USA.
Linda M. Liao, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Juhua Luo, Department of Epidemiology and Biostatistics, School of Public Health, Indiana University Bloomington, Bloomington, Indiana, USA.
Roger L. Milne, Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.
Katie M. O'Brien, Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Ulrike Peters, Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Jenny N. Poynter, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Mark P. Purdue, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Kim Robien, Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, District of Columbia, USA.
Sven Sandin, Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Dale P. Sandler, Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Veronica W. Setiawan, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jae H. Kang, Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Tracey G. Simon, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Rashmi Sinha, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Trang VoPham, Epidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Stephanie J. Weinstein, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Emily White, Epidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Xuehong Zhang, Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Document Type

Journal Article

Publication Date

6-1-2024

Journal

Hepatology (Baltimore, Md.)

Volume

79

Issue

6

DOI

10.1097/HEP.0000000000000748

Abstract

BACKGROUND AND AIMS: Tea and coffee are widely consumed beverages worldwide. We evaluated their association with biliary tract cancer (BTC) incidence. APPROACH AND RESULTS: We pooled data from 15 studies in the Biliary Tract Cancers Pooling Project to evaluate associations between tea and coffee consumption and biliary tract cancer development. We categorized participants as nondrinkers (0 cup/day), moderate drinkers (>0 and <3 cups/day), and heavy drinkers (≥3 cups/day). We estimated multivariable HRs and 95% CIs using Cox models. During 29,911,744 person-years of follow-up, 851 gallbladder, 588 intrahepatic bile duct, 753 extrahepatic bile duct, and 458 ampulla of Vater cancer cases were diagnosed. Individuals who drank tea showed a statistically significantly lower incidence rate of gallbladder cancer (GBC) relative to tea nondrinkers (HR=0.77; 95% CI, 0.64-0.91), and intrahepatic bile duct cancer (IHBDC) had an inverse association (HR=0.81; 95% CI, 0.66-1.00). However, no associations were observed for extrahepatic bile duct cancer (EHBDC) or ampulla of Vater cancer (AVC). In contrast, coffee consumption was positively associated with GBC, with a higher incidence rate for individuals consuming more coffee (HR<3 cups/day =1.29; 95% CI, 1.01-1.66; HR≥3 cups/day =1.49; 95% CI, 1.11-1.99, Ptrend=0.01) relative to coffee nondrinkers. However, there was no association between coffee consumption and GBC when restricted to coffee drinkers. There was little evidence of associations between coffee consumption and other biliary tract cancers. CONCLUSIONS: Tea consumption was associated with a lower incidence of GBC and possibly IHBDC. Further research is warranted to replicate the observed positive association between coffee and GBC.

Department

Exercise and Nutrition Sciences

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