Molecular and cellular neurocardiology in heart disease

Beth A. Habecker, Department of Chemical Physiology & Biochemistry, Department of Medicine Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA.
Donald M. Bers, Department of Pharmacology, University of California, Davis School of Medicine, Davis, CA, USA.
Susan J. Birren, Department of Biology, Volen Center for Complex Systems, Brandeis University, Waltham, MA, USA.
Rui Chang, Department of Neuroscience, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.
Neil Herring, Burdon Sanderson Cardiac Science Centre and BHF Centre of Research Excellence, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Matthew W. Kay, Department of Biomedical Engineering, George Washington University, Washington, DC, USA.
Dan Li, Burdon Sanderson Cardiac Science Centre and BHF Centre of Research Excellence, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
David Mendelowitz, Department of Pharmacology and Physiology, George Washington University, Washington, DC, USA.
Marco Mongillo, Department of Biomedical Sciences, University of Padova, Padova, Italy.
Johanna M. Montgomery, Department of Physiology and Manaaki Manawa Centre for Heart Research, University of Auckland, Auckland, New Zealand.
Crystal M. Ripplinger, Department of Pharmacology, University of California, Davis School of Medicine, Davis, CA, USA.
Emmanouil Tampakakis, Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Annika Winbo, Department of Physiology and Manaaki Manawa Centre for Heart Research, University of Auckland, Auckland, New Zealand.
Tania Zaglia, Department of Biomedical Sciences, University of Padova, Padova, Italy.
Nadja Zeltner, Departments of Biochemistry and Molecular Biology, Cell Biology, and Center for Molecular Medicine, University of Georgia, Athens, GA, USA.
David J. Paterson, Burdon Sanderson Cardiac Science Centre and BHF Centre of Research Excellence, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

Document Type

Journal Article

Publication Date

5-22-2024

Journal

The Journal of physiology

DOI

10.1113/JP284739

Keywords

CamKII; autonomic nervous system; cardiac physiology; cardiovascular disease; induced pluripotent stem cells; neuron‐myocyte co‐cultures; optical mapping; optogenetics

Abstract

This paper updates and builds on a previous White Paper in this journal that some of us contributed to concerning the molecular and cellular basis of cardiac neurobiology of heart disease. Here we focus on recent findings that underpin cardiac autonomic development, novel intracellular pathways and neuroplasticity. Throughout we highlight unanswered questions and areas of controversy. Whilst some neurochemical pathways are already demonstrating prognostic viability in patients with heart failure, we also discuss the opportunity to better understand sympathetic impairment by using patient specific stem cells that provides pathophysiological contextualization to study 'disease in a dish'. Novel imaging techniques and spatial transcriptomics are also facilitating a road map for target discovery of molecular pathways that may form a therapeutic opportunity to treat cardiac dysautonomia.

Department

Pharmacology and Physiology

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