Targeting Parasympathetic Activity to Improve Autonomic Tone and Clinical Outcomes

Authors

Matthew W. Kay, Department of Biomedical Engineering, George Washington University, Washington, District of Columbia.
Vivek Jain, Division of Pulmonary Medicine, Department of Medicine, George Washington University, Washington, District of Columbia.
Gurusher Panjrath, Division of Cardiology, Department of Medicine, George Washington University, Washington, District of Columbia.
David Mendelowitz, Department of Pharmacology and Physiology, George Washington University, Washington, District of Columbia.

Document Type

Journal Article

Publication Date

1-1-2022

Journal

Physiology (Bethesda, Md.)

Volume

37

Issue

1

DOI

10.1152/physiol.00023.2021

Keywords

OSA; autonomic; cardiac; heart failure; parasympathetic

Abstract

In this review we will briefly summarize the evidence that autonomic imbalance, more specifically reduced parasympathetic activity to the heart, generates and/or maintains many cardiorespiratory diseases and will discuss mechanisms and sites, from myocytes to the brain, that are potential translational targets for restoring parasympathetic activity and improving cardiorespiratory health.

APA Citation

Kay, Matthew W.; Jain, Vivek; Panjrath, Gurusher; and Mendelowitz, David, "Targeting Parasympathetic Activity to Improve Autonomic Tone and Clinical Outcomes" (2022). GW Authored Works. Paper 489.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/489

Department

Medicine