Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography
Document Type
Journal Article
Publication Date
5-27-2024
Journal
European heart journal
Volume
45
Issue
20
DOI
10.1093/eurheartj/ehae190
Keywords
Atherosclerotic cardiovascular disease; Coronary artery disease; Coronary computed tomography angiography; Major adverse cardiovascular events; Prevention
Abstract
Clinical risk scores based on traditional risk factors of atherosclerosis correlate imprecisely to an individual's complex pathophysiological predisposition to atherosclerosis and provide limited accuracy for predicting major adverse cardiovascular events (MACE). Over the past two decades, computed tomography scanners and techniques for coronary computed tomography angiography (CCTA) analysis have substantially improved, enabling more precise atherosclerotic plaque quantification and characterization. The accuracy of CCTA for quantifying stenosis and atherosclerosis has been validated in numerous multicentre studies and has shown consistent incremental prognostic value for MACE over the clinical risk spectrum in different populations. Serial CCTA studies have advanced our understanding of vascular biology and atherosclerotic disease progression. The direct disease visualization of CCTA has the potential to be used synergistically with indirect markers of risk to significantly improve prevention of MACE, pending large-scale randomized evaluation.
APA Citation
Nurmohamed, Nick S.; van Rosendael, Alexander R.; Danad, Ibrahim; Ngo-Metzger, Quyen; Taub, Pam R.; Ray, Kausik K.; Figtree, Gemma; Bonaca, Marc P.; Hsia, Judith; Rodriguez, Fatima; Sandhu, Alexander T.; Nieman, Koen; Earls, James P.; Hoffmann, Udo; Bax, Jeroen J.; Min, James K.; Maron, David J.; and Bhatt, Deepak L., "Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography" (2024). GW Authored Works. Paper 4877.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/4877
Department
Radiology