Integrated Short-TE and Hadamard-edited Multi-Sequence (ISTHMUS) for Advanced MRS

Steve C. Hui, Developing Brain Institute, Children's National Hospital, Washington, D.C. USA.
Saipavitra Murali-Manohar, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Helge J. Zöllner, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kathleen E. Hupfeld, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christopher W. Davies-Jenkins, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Aaron T. Gudmundson, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yulu Song, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Vivek Yedavalli, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jessica L. Wisnowski, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Borjan Gagoski, Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.
Georg Oeltzschner, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Richard A. Edden, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Document Type

Journal Article

Publication Date

4-18-2024

Journal

bioRxiv : the preprint server for biology

DOI

10.1101/2024.02.15.580516

Keywords

HBCD; Hadamard encoding; MR spectroscopy; PRESS; Spectral editing

Abstract

BACKGROUND: To examine data quality and reproducibility using ISTHMUS, which has been implemented as the standardized MR spectroscopy sequence for the multi-site Healthy Brain and Child Development (HBCD) study. METHODS: ISTHMUS is the consecutive acquisition of short-TE PRESS (32 transients) and long-TE HERCULES (224 transients) data with dual-TE water reference scans. Voxels were positioned in the centrum semiovale, dorsal anterior cingulate cortex, posterior cingulate cortex and bilateral thalamus regions. After acquisition, ISTHMUS data were separated into the PRESS and HERCULES portions for analysis and modeled separately using Osprey. In vivo experiments were performed in 10 healthy volunteers (6 female; 29.5±6.6 years). Each volunteer underwent two scans on the same day. Differences in metabolite measurements were examined. T correction based on the dual-TE water integrals were compared with: 1) T correction based the default white matter and gray matter T reference values in Osprey; 2) shorter WM and GM T values from recent literature; and 3) reduced CSF fractions. RESULTS: No significant difference in linewidth was observed between PRESS and HERCULES. Bilateral thalamus spectra had produced significantly higher (p<0.001) linewidth compared to the other three regions. Linewidth measurements were similar between scans, with scan-to-scan differences under 1 Hz for most subjects. Paired t-tests indicated a significant difference only in PRESS NAAG between the two thalamus scans (p=0.002). T correction based on shorter T values showed better agreement to the dual-TE water integral ratio. CONCLUSIONS: ISTHMUS facilitated and standardized acquisition and post-processing and reduced operator workload to eliminate potential human error.

Department

Radiology

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