Patients Who Have Prior Solid Organ Transplants Have Increased Risk Of 10-Year Periprosthetic Joint Infection Revision Following Primary Total Knee Arthroplasty: A Propensity Matched Analysis

Authors

Arnav Gupta, Department of Orthopaedic Surgery, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia. Electronic address: arnav_gupta@gwu.edu.
Correggio Peagler, Department of Orthopaedic Surgery, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
Amy Zhao, Department of Orthopaedic Surgery, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
Amil R. Agarwal, Department of Orthopaedic Surgery, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia; Department of Orthopaedic Surgery, The Johns Hopkins Hospital, Baltimore, MD.
Christa LiBrizzi, Department of Orthopaedic Surgery, The Johns Hopkins Hospital, Baltimore, MD.
Alex Gu, Department of Orthopaedic Surgery, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.
Adam S. Levin, Department of Orthopaedic Surgery, The Johns Hopkins Hospital, Baltimore, MD.
Savyasachi C. Thakkar, Johns Hopkins Department of Orthopaedic Surgery, Adult Reconstruction Division, Columbia, MD.

Document Type

Journal Article

Publication Date

4-23-2024

Journal

The Journal of arthroplasty

DOI

10.1016/j.arth.2024.04.052

Abstract

BACKGROUND: Total knee arthroplasty (TKA) for solid organ transplant (SOT) patients is becoming more prominent as life expectancy in this population increases. However, data on long-term (10 year) implant survivorship in this cohort is sparse. The purpose of this study was to compare 90-day, 2-year, 5-year, and 10-year implant survivability following primary TKA in patients who did and did not have prior SOT. METHODS: The PearlDiver database was utilized to query patients who underwent unilateral elective TKA with at least 2 years of active follow-up. These patients were stratified into those who had a SOT before TKA and those who did not. The SOT cohort was propensity-matched to control patients based on age, sex, Charlson Comorbidity Index, and obesity in a 1:2 ratio. Cumulative incidence (CI) rates and hazard ratios (HR) were compared between the SOT, matched, and unmatched cohorts. RESULTS: No difference was observed in 10-year CI and risk of all-cause revision surgery in TKA patients with prior SOT when compared to matched and unmatched controls. Compared to the matched control, the SOT cohort had no difference in the risk of revision when stratified by indication and timing. However, when compared to the unmatched control, patients who had prior SOT had a higher risk for revision due to periprosthetic joint infection (PJI) at 10 years (HR: 1.80; 95% Confidence Interval: 1.17 to 2.76) as well as all-cause revision within 90 days after TKA (HR: 1.93; 95% Confidence Interval: 1.10 to 3.36). CONCLUSION: Prior SOT patients have higher rates of all-cause revision within 90 days and PJI within 10 years when compared to the general population, likely associated with the elevated number of comorbidities in SOT patients and not the transplant itself. Therefore, these patients should be monitored in the preoperative and early postoperative settings to optimize their known comorbidities.

APA Citation

Gupta, Arnav; Peagler, Correggio; Zhao, Amy; Agarwal, Amil R.; LiBrizzi, Christa; Gu, Alex; Levin, Adam S.; and Thakkar, Savyasachi C., "Patients Who Have Prior Solid Organ Transplants Have Increased Risk Of 10-Year Periprosthetic Joint Infection Revision Following Primary Total Knee Arthroplasty: A Propensity Matched Analysis" (2024). GW Authored Works. Paper 4681.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/4681

Department

School of Medicine and Health Sciences Student Works