Pediatric cutaneous T-cell neoplasm and mimics with gamma-delta expression: Not always aggressive

Authors

Jinjun Cheng, Department of Pathology and Laboratory Medicine, Children's National Hospital, Washington, District of Columbia, USA.
Keri Toner, Center for Cancer and Immunology Research, Children's National Hospital, Washington, District of Columbia, USA.
Kaiane Habeshian, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.
Michael Cardis, Department of Dermatology, Medstar-Georgetown University School of Medicine, Washington, District of Columbia, USA.
Edward W. Cowen, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Health, Bethesda, Maryland, USA.
Catherine M. Bollard, Center for Cancer and Immunology Research, Children's National Hospital, Washington, District of Columbia, USA.
Birte Wistinghausen, Center for Cancer and Immunology Research, Children's National Hospital, Washington, District of Columbia, USA.
A Yasmine Kirkorian, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.

Document Type

Journal Article

Publication Date

3-1-2024

Journal

Pediatric blood & cancer

Volume

71

Issue

3

DOI

10.1002/pbc.30837

Keywords

CTCL; MF; PCGDTCL; PLC; SPTCL

Abstract

Pediatric cutaneous T-cell lymphoma with γδ immunophenotype is extremely rare. Only a few cases of γδ T-cell neoplasm have been reported in the literature, and therefore little is known whether γδ T-cell neoplasms in children are distinct from their adult counterparts with respect to the clinicopathological presentation, behavior, and prognosis. In this study, we demonstrate three unique pediatric cutaneous T-cell neoplasm and mimics with increased γδ T cells. All cases showed an indolent clinical course.

APA Citation

Cheng, Jinjun; Toner, Keri; Habeshian, Kaiane; Cardis, Michael; Cowen, Edward W.; Bollard, Catherine M.; Wistinghausen, Birte; and Kirkorian, A Yasmine, "Pediatric cutaneous T-cell neoplasm and mimics with gamma-delta expression: Not always aggressive" (2024). GW Authored Works. Paper 4632.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/4632

Department

Pediatrics