Exercise for patients with chronic kidney disease: from cells to systems to function

Authors

Jared M. Gollie, Research and Development Service, Washington DC Veterans Affairs Medical Center, Washington, District of Columbia, United States.
Alice S. Ryan, Department of Medicine, University of Maryland, Baltimore, Maryland, United States.
Sabyasachi Sen, Department of Medicine, Washington DC Veterans Affairs, Medical Center, Washington, District of Columbia, United States.
Samir S. Patel, Research and Development Service, Washington DC Veterans Affairs Medical Center, Washington, District of Columbia, United States.
Peter F. Kokkinos, Division of Cardiology, Washington DC Veterans Affairs Medical Center, Washington, District of Columbia, United States.
Michael O. Harris-Love, Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
Joel D. Scholten, Physical Medicine and Rehabilitation Service, Washington DC Veterans Affairs Medical Center, Washington, District of Columbia, United States.
Marc R. Blackman, Research and Development Service, Washington DC Veterans Affairs Medical Center, Washington, District of Columbia, United States.

Document Type

Journal Article

Publication Date

3-1-2024

Journal

American journal of physiology. Renal physiology

Volume

326

Issue

3

DOI

10.1152/ajprenal.00302.2023

Keywords

endothelial function; exercise; oxygen consumption; renal failure; strength

Abstract

Chronic kidney disease (CKD) is among the leading causes of death and disability, affecting an estimated 800 million adults globally. The underlying pathophysiology of CKD is complex creating challenges to its management. Primary risk factors for the development and progression of CKD include diabetes mellitus, hypertension, age, obesity, diet, inflammation, and physical inactivity. The high prevalence of diabetes and hypertension in patients with CKD increases the risk for secondary consequences such as cardiovascular disease and peripheral neuropathy. Moreover, the increased prevalence of obesity and chronic levels of systemic inflammation in CKD have downstream effects on critical cellular functions regulating homeostasis. The combination of these factors results in the deterioration of health and functional capacity in those living with CKD. Exercise offers protective benefits for the maintenance of health and function with age, even in the presence of CKD. Despite accumulating data supporting the implementation of exercise for the promotion of health and function in patients with CKD, a thorough description of the responses and adaptations to exercise at the cellular, system, and whole body levels is currently lacking. Therefore, the purpose of this review is to provide an up-to-date comprehensive review of the effects of exercise training on vascular endothelial progenitor cells at the cellular level; cardiovascular, musculoskeletal, and neural factors at the system level; and physical function, frailty, and fatigability at the whole body level in patients with CKD.

APA Citation

Gollie, Jared M.; Ryan, Alice S.; Sen, Sabyasachi; Patel, Samir S.; Kokkinos, Peter F.; Harris-Love, Michael O.; Scholten, Joel D.; and Blackman, Marc R., "Exercise for patients with chronic kidney disease: from cells to systems to function" (2024). GW Authored Works. Paper 4627.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/4627

Department

Medicine