Applications of nitric oxide-releasing nanomaterials in dermatology: Skin infections and wound healing

Authors

Sara Abdel Azim, Georgetown University School of Medicine, Washington, DC, USA.
Cleo Whiting, Department of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Adam J. Friedman, Department of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA. Electronic address: ajfriedman@mfa.gwu.edu.

Document Type

Journal Article

Publication Date

3-6-2024

Journal

Nitric oxide : biology and chemistry

Volume

146

DOI

10.1016/j.niox.2024.03.001

Keywords

Acne vulgaris; Antimicrobial; Nanotechnology; Nitric oxide; Skin and soft-tissue infection; Wound healing

Abstract

Nitric oxide (NO) is produced in most cells in the skin and is an important regulator of essential cutaneous functions, including responses to UV irradiation, microbial defense, wound healing, melanogenesis and epidermal permeability barrier homeostasis. Harnessing the physiological activities of NO for therapeutic use is difficult because the molecule is highly reactive and unstable. A variety of exogenous NO delivery platforms have been developed and evaluated; however, they have limited clinical applications in dermatology due to instability and poor cutaneous penetration. NO-releasing nanomaterials overcome these limitations, providing targeted tissue delivery, and sustained and controlled NO release. This review provides a comprehensive and up-to-date evaluation of the use of NO-releasing nanomaterials in dermatology for the treatment of skin and soft tissue infections and wound healing.

APA Citation

Abdel Azim, Sara; Whiting, Cleo; and Friedman, Adam J., "Applications of nitric oxide-releasing nanomaterials in dermatology: Skin infections and wound healing" (2024). GW Authored Works. Paper 4555.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/4555

Department

Dermatology