Histopathology of congestive nephropathy: a case description and literature review

Authors

Faeq Husain-Syed, Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Germany.
Janani Rangaswami, George Washington University School of Medicine, Washington, DC, USA.
Julio Núñez, Department of Cardiology, Hospital Clínico Universitario de Valencia (INCLIVA), Valencia, Spain.
Susanne Skrzypek, Pediatric Heart Centre, Centre for Congenital Heart Disease, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Germany.
Christian Jux, Pediatric Heart Centre, Centre for Congenital Heart Disease, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Germany.
Hermann-Josef Gröne, Department of Pharmacology, University of Marburg, Marburg, Germany.
Horst-Walter Birk, Department of Internal Medicine II, University Hospital Giessen and Marburg, Justus-Liebig-University Giessen, Giessen, Germany.

Document Type

Journal Article

Publication Date

3-11-2024

Journal

ESC heart failure

DOI

10.1002/ehf2.14760

Keywords

Acute heart failure; Acute kidney injury; Cardiorenal syndrome; Worsening renal function

Abstract

Congestive nephropathy is an underappreciated manifestation of cardiorenal syndrome and is characterized by a potentially reversible kidney dysfunction caused by a reduced renal venous outflow secondary to right-sided heart failure or intra-abdominal hypertension. To date, the histological diagnostic criteria for congestive nephropathy have not been defined. We herein report a case of acute renal dysfunction following cardiac allograft failure and present a review of the relevant literature to elucidate the current understanding of the disease. Our case demonstrated that congestion-driven nephropathy may be histopathologically characterized by markedly dilated veins and peritubular capillaries, focally accentuated low-grade acute tubular damage, small areas of interstitial fibrosis, and tubular atrophy on a background of normal glomeruli and predominantly normal tubular cell differentiation.

APA Citation

Husain-Syed, Faeq; Rangaswami, Janani; Núñez, Julio; Skrzypek, Susanne; Jux, Christian; Gröne, Hermann-Josef; and Birk, Horst-Walter, "Histopathology of congestive nephropathy: a case description and literature review" (2024). GW Authored Works. Paper 4542.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/4542

Department

Medicine