Abnormal Neurologic Findings in Patients With Sickle Cell Disease Without a History of Major Neurologic Events
Authors
Mohammed B. Nawaiseh, Department of Ophthalmology (MBN), Jordanian Royal Medical Services, Amman; Department of Neurology (AMY), Jordan University of Science and Technology, Irbid, Jordan; Department of Neurology (MQAS), Kansas University Medical Center, Kansas City; Department of Internal Medicine (AA), St. Elizabeth's Medical Center, Boston, MA; Department of Internal Medicine (HZ), Cleveland Clinic, OH; Department of Internal Medicine (DAA), Henry Ford Health System, Detroit, MI; Department of Internal Medicine (RRH), JCESOM, Marshall University, WV; Department of Clinical Sciences (ME-G), College of Medicine, University of Houston, HCA Northwest Medical Center, Houston, TX; and Department of Neurology (MA-R), George Washington University, Washington, DC.
Ahmed M. Yassin, Department of Ophthalmology (MBN), Jordanian Royal Medical Services, Amman; Department of Neurology (AMY), Jordan University of Science and Technology, Irbid, Jordan; Department of Neurology (MQAS), Kansas University Medical Center, Kansas City; Department of Internal Medicine (AA), St. Elizabeth's Medical Center, Boston, MA; Department of Internal Medicine (HZ), Cleveland Clinic, OH; Department of Internal Medicine (DAA), Henry Ford Health System, Detroit, MI; Department of Internal Medicine (RRH), JCESOM, Marshall University, WV; Department of Clinical Sciences (ME-G), College of Medicine, University of Houston, HCA Northwest Medical Center, Houston, TX; and Department of Neurology (MA-R), George Washington University, Washington, DC.
Mohammed Q. Al-Sabbagh, Department of Ophthalmology (MBN), Jordanian Royal Medical Services, Amman; Department of Neurology (AMY), Jordan University of Science and Technology, Irbid, Jordan; Department of Neurology (MQAS), Kansas University Medical Center, Kansas City; Department of Internal Medicine (AA), St. Elizabeth's Medical Center, Boston, MA; Department of Internal Medicine (HZ), Cleveland Clinic, OH; Department of Internal Medicine (DAA), Henry Ford Health System, Detroit, MI; Department of Internal Medicine (RRH), JCESOM, Marshall University, WV; Department of Clinical Sciences (ME-G), College of Medicine, University of Houston, HCA Northwest Medical Center, Houston, TX; and Department of Neurology (MA-R), George Washington University, Washington, DC.
Ahmad AlNawaiseh, Department of Ophthalmology (MBN), Jordanian Royal Medical Services, Amman; Department of Neurology (AMY), Jordan University of Science and Technology, Irbid, Jordan; Department of Neurology (MQAS), Kansas University Medical Center, Kansas City; Department of Internal Medicine (AA), St. Elizabeth's Medical Center, Boston, MA; Department of Internal Medicine (HZ), Cleveland Clinic, OH; Department of Internal Medicine (DAA), Henry Ford Health System, Detroit, MI; Department of Internal Medicine (RRH), JCESOM, Marshall University, WV; Department of Clinical Sciences (ME-G), College of Medicine, University of Houston, HCA Northwest Medical Center, Houston, TX; and Department of Neurology (MA-R), George Washington University, Washington, DC.
Hadil Zureigat, Department of Ophthalmology (MBN), Jordanian Royal Medical Services, Amman; Department of Neurology (AMY), Jordan University of Science and Technology, Irbid, Jordan; Department of Neurology (MQAS), Kansas University Medical Center, Kansas City; Department of Internal Medicine (AA), St. Elizabeth's Medical Center, Boston, MA; Department of Internal Medicine (HZ), Cleveland Clinic, OH; Department of Internal Medicine (DAA), Henry Ford Health System, Detroit, MI; Department of Internal Medicine (RRH), JCESOM, Marshall University, WV; Department of Clinical Sciences (ME-G), College of Medicine, University of Houston, HCA Northwest Medical Center, Houston, TX; and Department of Neurology (MA-R), George Washington University, Washington, DC.
Dina Aljbour AlMajali, Department of Ophthalmology (MBN), Jordanian Royal Medical Services, Amman; Department of Neurology (AMY), Jordan University of Science and Technology, Irbid, Jordan; Department of Neurology (MQAS), Kansas University Medical Center, Kansas City; Department of Internal Medicine (AA), St. Elizabeth's Medical Center, Boston, MA; Department of Internal Medicine (HZ), Cleveland Clinic, OH; Department of Internal Medicine (DAA), Henry Ford Health System, Detroit, MI; Department of Internal Medicine (RRH), JCESOM, Marshall University, WV; Department of Clinical Sciences (ME-G), College of Medicine, University of Houston, HCA Northwest Medical Center, Houston, TX; and Department of Neurology (MA-R), George Washington University, Washington, DC.
Rund R. Haddadin, Department of Ophthalmology (MBN), Jordanian Royal Medical Services, Amman; Department of Neurology (AMY), Jordan University of Science and Technology, Irbid, Jordan; Department of Neurology (MQAS), Kansas University Medical Center, Kansas City; Department of Internal Medicine (AA), St. Elizabeth's Medical Center, Boston, MA; Department of Internal Medicine (HZ), Cleveland Clinic, OH; Department of Internal Medicine (DAA), Henry Ford Health System, Detroit, MI; Department of Internal Medicine (RRH), JCESOM, Marshall University, WV; Department of Clinical Sciences (ME-G), College of Medicine, University of Houston, HCA Northwest Medical Center, Houston, TX; and Department of Neurology (MA-R), George Washington University, Washington, DC.
Mohammad El-Ghanem, Department of Ophthalmology (MBN), Jordanian Royal Medical Services, Amman; Department of Neurology (AMY), Jordan University of Science and Technology, Irbid, Jordan; Department of Neurology (MQAS), Kansas University Medical Center, Kansas City; Department of Internal Medicine (AA), St. Elizabeth's Medical Center, Boston, MA; Department of Internal Medicine (HZ), Cleveland Clinic, OH; Department of Internal Medicine (DAA), Henry Ford Health System, Detroit, MI; Department of Internal Medicine (RRH), JCESOM, Marshall University, WV; Department of Clinical Sciences (ME-G), College of Medicine, University of Houston, HCA Northwest Medical Center, Houston, TX; and Department of Neurology (MA-R), George Washington University, Washington, DC.
Mohammad Abu-Rub, Department of Ophthalmology (MBN), Jordanian Royal Medical Services, Amman; Department of Neurology (AMY), Jordan University of Science and Technology, Irbid, Jordan; Department of Neurology (MQAS), Kansas University Medical Center, Kansas City; Department of Internal Medicine (AA), St. Elizabeth's Medical Center, Boston, MA; Department of Internal Medicine (HZ), Cleveland Clinic, OH; Department of Internal Medicine (DAA), Henry Ford Health System, Detroit, MI; Department of Internal Medicine (RRH), JCESOM, Marshall University, WV; Department of Clinical Sciences (ME-G), College of Medicine, University of Houston, HCA Northwest Medical Center, Houston, TX; and Department of Neurology (MA-R), George Washington University, Washington, DC.
Document Type
Journal Article
Publication Date
2-1-2024
Journal
Neurology. Clinical practice
DOI
10.1212/CPJ.0000000000200215
Abstract
BACKGROUND AND OBJECTIVES: Patients with sickle cell disease (SCD) are prone to symptomatic neurologic complications. Previous studies reported accrual of neural injury starting at early age, even without having symptomatic neurologic events. The aim of this study was to assess the prevalence and risk factors of abnormal neurologic findings in patients with SCD with no history of major symptomatic neurologic events. METHODS: Our study extracted patients diagnosed with SCD from the Cooperative Study of Sickle Cell Disease. Patients who underwent a neurologic evaluation were included in our analysis. Patients with previous documented major symptomatic neurologic events were excluded. We compared patients with SCD with abnormal neurologic findings with those without in terms of clinical and laboratory parameters using multivariate binary logistic regression. RESULTS: A total of 3,573 patients with SCD were included (median age = 11 [IQR = 19] years, male = 1719 [48.1%]). 519 (14.5%) patients had at least one abnormal neurologic finding. The most common findings in descending order were abnormal reflexes, gait abnormalities, cerebellar dysfunction, language deficits, nystagmus, abnormal muscle tone and strength, Romberg sign, Horner syndrome, and intellectual impairment. History of eye disease (odds ratio [OR] = 2.76, 95% confidence interval [CI] = 1.63-4.68) and history of osteomyelitis (OR = 2.55, 95% CI 1.34-4.84) were the strongest predictors of abnormal neurologic findings, followed by smoking (OR = 1.59, 95% CI 1.08-2.33), aseptic necrosis (OR = 1.57, 95% CI 1.06-2.33), hand-foot syndrome (OR = 1.48, 95% CI 1.04-2.12), and male sex (OR = 1.42, 95% CI 1.01-2.02). DISCUSSION: Neurologic deficits are relatively common in patients with SCD, even without documented major neurologic insults. They range from peripheral and ophthalmic deficits to central and cognitive disabilities. Patients with SCD should have early regular neurologic evaluations and risk factor modification, particularly actively promoting smoking cessation.
APA Citation
Nawaiseh, Mohammed B.; Yassin, Ahmed M.; Al-Sabbagh, Mohammed Q.; AlNawaiseh, Ahmad; Zureigat, Hadil; Aljbour AlMajali, Dina; Haddadin, Rund R.; El-Ghanem, Mohammad; and Abu-Rub, Mohammad, "Abnormal Neurologic Findings in Patients With Sickle Cell Disease Without a History of Major Neurologic Events" (2024). GW Authored Works. Paper 4432.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/4432
