Spike-directed vaccination elicits robust spike-specific T-cell response, including to mutant strains
COVID-19 variants; SARS-CoV-2; T-cell responses to coronavirus; vaccination
Although most studies describing coronavirus disease 2019 vaccine responses have focused on antibodies, there is increasing evidence that T cells play a critical role. Here the authors evaluated T-cell responses in seronegative donors before and after vaccination to define responses to the severe acute respiratory syndrome coronavirus 2 reference strain as well as to mutations in the variant strains Alpha/B.1.1.7 and Beta/B.1.351. The authors observed enhanced T-cell responses to reference and variant spike strains post-vaccination.
Stanojevic, Maja; Geiger, Ashley; Ostermeier, Brita; Sohai, Danielle; Lazarski, Christopher; Lang, Haili; Jensen-Wachspress, Mariah; Webber, Kathleen; Burbelo, Peter; Cohen, Jeffrey; Keller, Michael D.; Bollard, Catherine M.; and Cruz, Conrad Russell, "Spike-directed vaccination elicits robust spike-specific T-cell response, including to mutant strains" (2022). GW Authored Works. Paper 437.