Spike-directed vaccination elicits robust spike-specific T-cell response, including to mutant strains

Authors

• Maja Stanojevic, Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Medical Center, Washington, DC, USA.
• Ashley Geiger, Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Medical Center, Washington, DC, USA.
• Brita Ostermeier, Institute for Biomedical Sciences, George Washington University, Washington, DC, USA.
• Danielle Sohai, Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Medical Center, Washington, DC, USA.
• Christopher Lazarski, Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Medical Center, Washington, DC, USA.
• Haili Lang, Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Medical Center, Washington, DC, USA.
• Mariah Jensen-Wachspress, Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Medical Center, Washington, DC, USA.
• Kathleen Webber, Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Medical Center, Washington, DC, USA.
• Peter Burbelo, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
• Jeffrey Cohen, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, USA.
• Michael D. Keller, Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Medical Center, Washington, DC, USA.
• Catherine M. Bollard, Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Medical Center, Washington, DC, USA. Electronic address: cbollard@childrensnational.org.
• Conrad Russell Cruz, Program for Cell Enhancement and Technologies for Immunotherapy, Children's National Medical Center, Washington, DC, USA. Electronic address: ccruz@childrensnational.org.

Document Type

Journal Article

Publication Date

1-1-2022

Journal

Cytotherapy

Volume

24

Issue

1

DOI

10.1016/j.jcyt.2021.07.006

Keywords

COVID-19 variants; SARS-CoV-2; T-cell responses to coronavirus; vaccination

Abstract

Although most studies describing coronavirus disease 2019 vaccine responses have focused on antibodies, there is increasing evidence that T cells play a critical role. Here the authors evaluated T-cell responses in seronegative donors before and after vaccination to define responses to the severe acute respiratory syndrome coronavirus 2 reference strain as well as to mutations in the variant strains Alpha/B.1.1.7 and Beta/B.1.351. The authors observed enhanced T-cell responses to reference and variant spike strains post-vaccination.

APA Citation

Stanojevic, Maja; Geiger, Ashley; Ostermeier, Brita; Sohai, Danielle; Lazarski, Christopher; Lang, Haili; Jensen-Wachspress, Mariah; Webber, Kathleen; Burbelo, Peter; Cohen, Jeffrey; Keller, Michael D.; Bollard, Catherine M.; and Cruz, Conrad Russell, "Spike-directed vaccination elicits robust spike-specific T-cell response, including to mutant strains" (2022). GW Authored Works. Paper 437.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/437

Department

Pediatrics