Communicating computational workflows in a regulatory environment

Authors

Jonathon G. Keeney, Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA. Electronic address: keeneyjg@gwu.edu.
Naila Gulzar, Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
Jack B. Baker, Merck & Co., Kenilworth, NJ, USA.
Ondrej Klempir, R&D Informatics Solutions, MSD Czech Republic, Prague, Czech Republic.
Geoffrey D. Hannigan, Exploratory Science Center, Merck & Co., Cambridge, MA, USA.
Danny A. Bitton, R&D Informatics Solutions, MSD Czech Republic, Prague, Czech Republic.
Julia M. Maritz, Exploratory Science Center, Merck & Co., Cambridge, MA, USA.
Charles H. King, Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
Janisha A. Patel, Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
Paul Duncan, Merck & Co., Kenilworth, NJ, USA.
Raja Mazumder, Department of Biochemistry and Molecular Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.

Document Type

Journal Article

Publication Date

1-12-2024

Journal

Drug discovery today

DOI

10.1016/j.drudis.2024.103884

Keywords

BioCompute; HTS; adventitious virus detection; metagenomics; next generation sequencing; vaccine

Abstract

The volume of nucleic acid sequence data has exploded recently, amplifying the challenge of transforming data into meaningful information. Processing data can require an increasingly complex ecosystem of customized tools, which increases difficulty in communicating analyses in an understandable way yet is of sufficient detail to enable informed decisions or repeats. This can be of particular interest to institutions and companies communicating computations in a regulatory environment. BioCompute Objects (BCOs; an instance of pipeline documentation that conforms to the IEEE 2791-2020 standard) were developed as a standardized mechanism for analysis reporting. A suite of BCOs is presented, representing interconnected elements of a computation modeled after those that might be found in a regulatory submission but are shared publicly - in this case a pipeline designed to identify viral contaminants in biological manufacturing, such as for vaccines.

APA Citation

Keeney, Jonathon G.; Gulzar, Naila; Baker, Jack B.; Klempir, Ondrej; Hannigan, Geoffrey D.; Bitton, Danny A.; Maritz, Julia M.; King, Charles H.; Patel, Janisha A.; Duncan, Paul; and Mazumder, Raja, "Communicating computational workflows in a regulatory environment" (2024). GW Authored Works. Paper 4182.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/4182

Department

Biochemistry and Molecular Medicine