Upregulated hepatic lipogenesis from dietary sugars in response to low palmitate feeding supplies brain palmitate

Authors

Mackenzie E. Smith, Department of Nutritional Sciences, University of Toronto, 1 King's College Circle, Toronto, M5S 1A8, ON, Canada.
Chuck T. Chen, Department of Nutritional Sciences, University of Toronto, 1 King's College Circle, Toronto, M5S 1A8, ON, Canada.
Chiraag A. Gohel, Department of Biostatistics and Bioinformatics, George Washington University, 950 New Hampshire Ave, NW, Washington, DC, 20052, USA.
Giulia Cisbani, Department of Nutritional Sciences, University of Toronto, 1 King's College Circle, Toronto, M5S 1A8, ON, Canada.
Daniel K. Chen, Department of Nutritional Sciences, University of Toronto, 1 King's College Circle, Toronto, M5S 1A8, ON, Canada.
Kimia Rezaei, Department of Nutritional Sciences, University of Toronto, 1 King's College Circle, Toronto, M5S 1A8, ON, Canada.
Andrew McCutcheon, Department of Nutritional Sciences, University of Toronto, 1 King's College Circle, Toronto, M5S 1A8, ON, Canada.
Richard P. Bazinet, Department of Nutritional Sciences, University of Toronto, 1 King's College Circle, Toronto, M5S 1A8, ON, Canada. richard.bazinet@utoronto.ca.

Document Type

Journal Article

Publication Date

1-17-2024

Journal

Nature communications

Volume

15

Issue

1

DOI

10.1038/s41467-023-44388-4

Abstract

Palmitic acid (PAM) can be provided in the diet or synthesized via de novo lipogenesis (DNL), primarily, from glucose. Preclinical work on the origin of brain PAM during development is scarce and contrasts results in adults. In this work, we use naturally occurring carbon isotope ratios (C/C; δC) to uncover the origin of brain PAM at postnatal days 0, 10, 21 and 35, and RNA sequencing to identify the pathways involved in maintaining brain PAM, at day 35, in mice fed diets with low, medium, and high PAM from birth. Here we show that DNL from dietary sugars maintains the majority of brain PAM during development and is augmented in mice fed low PAM. Importantly, the upregulation of hepatic DNL genes, in response to low PAM at day 35, demonstrates the presence of a compensatory mechanism to maintain total brain PAM pools compared to the liver; suggesting the importance of brain PAM regulation.

APA Citation

Smith, Mackenzie E.; Chen, Chuck T.; Gohel, Chiraag A.; Cisbani, Giulia; Chen, Daniel K.; Rezaei, Kimia; McCutcheon, Andrew; and Bazinet, Richard P., "Upregulated hepatic lipogenesis from dietary sugars in response to low palmitate feeding supplies brain palmitate" (2024). GW Authored Works. Paper 4165.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/4165

Department

Public Health Student Works