Race and Ethnic Group Enrollment and Outcomes for Wilms Tumor: Analysis of the Current Era Children's Oncology Group Study AREN03B2
Document Type
Journal Article
Publication Date
1-22-2024
Journal
Journal of the American College of Surgeons
DOI
10.1097/XCS.0000000000000999
Abstract
INTRODUCTION: To review race and ethnic group enrollment and outcomes for Wilms tumor (WT) across all four risk-assigned therapeutic trials from the current era Children's Oncology Group Renal Tumor Biology and Risk Stratification Protocol, AREN03B2. METHODS: For WT patients enrolled on AREN03B2 (2006-2019), disease and biologic features, therapeutic study-specific enrollment, and event-free (EFS) and overall (OS) 4-year survival were compared between institutionally reported race and ethnic groups. RESULTS: Among 5,146 WT patients, no statistically significant differences were detected between race and ethnic groups regarding subsequent risk-assigned therapeutic study enrollment, disease stage, histology, biologic factors, or overall EFS or OS, except the following variables: Black children were older and had larger tumors at enrollment, while Hispanic children had lower rates of diffuse anaplasia (DAWT) and LOH at 1p. The only significant difference in EFS or OS between race and ethnic groups was observed among the few children treated for DAWT with Regimen UH-1/2 on high-risk protocol, AREN0321. On this therapeutic arm only, Black children showed worse EFS (HR=3.18) and OS (HR=3.42). However, this finding was not replicated for patients treated with Regimen UH-1/2 under AREN03B2 but not on AREN0321. CONCLUSION: Race and ethnic group enrollment appeared constant across AREN03B2 risk-assigned therapeutic trials. EFS and OS on these therapeutic trials when analyzed together were comparable regarding race and ethnicity. Black children may have experienced worse stage-specific survival when treated with Regimen UH-1/2 on AREN0321, but this survival gap was not confirmed when analyzing additional high-risk AREN03B2 patients.
APA Citation
Lovvorn Iii, Harold N.; Renfro, Lindsay A.; Benedetti, Daniel J.; Kotagal, Meera; Phelps, Hannah M.; Ehrlich, Peter F.; Lo, Andrea C.; Sandberg, Jesse K.; Treece, Amanda L.; Gow, Kenneth W.; Glick, Richard D.; Davidoff, Andrew M.; Cost, Nicholas G.; Dix, David B.; Fernandez, Conrad V.; Dome, Jeffrey S.; Geller, James I.; and Mullen, Elizabeth A., "Race and Ethnic Group Enrollment and Outcomes for Wilms Tumor: Analysis of the Current Era Children's Oncology Group Study AREN03B2" (2024). GW Authored Works. Paper 4143.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/4143
Department
Pediatrics