Treatment preferences among patients with mild-to-moderate atopic dermatitis

Authors

Kelley Myers, RTI Health Solutions, Research Triangle Park, NC, USA.
Jonathan I. Silverberg, School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.
Shreekant Parasuraman, Incyte Corporation, Wilmington, DE, USA.
Anna Pierce, RTI Health Solutions, Research Triangle Park, NC, USA.
Lawrence F. Eichenfield, Departments of Dermatology and Pediatrics, University of California San Diego, San Diego, CA, USA.
Christine Poulos, RTI Health Solutions, Research Triangle Park, NC, USA.

Document Type

Journal Article

Publication Date

12-1-2023

Journal

The Journal of dermatological treatment

Volume

34

Issue

1

DOI

10.1080/09546634.2023.2215356

Keywords

Discrete choice experiment; atopic dermatitis; patient preferences

Abstract

New treatments for atopic dermatitis (AD) are emerging; however, little is known about the treatment preferences of patients with mild-to-moderate AD. To measure patients' preferences, a cross-sectional, web-based discrete choice experiment (DCE) survey was developed and administered to 300 adults in the United States with a self-reported physician diagnosis of mild-to-moderate AD. In the DCE, respondents evaluated pairs of hypothetical AD treatment profiles defined by efficacy, risk, and mode and frequency of administration attributes. The DCE data were analyzed using a random parameters logit model. Subgroup analysis was used to investigate preference heterogeneity. The results revealed achieving clear or almost clear skin within 3-4 months of treatment was the most important attribute relative to all other study attributes. The results indicated that a topical cream applied twice daily was preferred to systemic treatments. Subgroup analysis revealed that respondents with lower self-assessed disease burden were more likely to choose topical over systemic treatments and less averse to the risk of pain, burning, and/or stinging from the medicine (all other treatment features remaining equal) than respondents with higher self-assessed disease burden. The results of this study can help inform shared decision-making to manage mild-to-moderate AD.

APA Citation

Myers, Kelley; Silverberg, Jonathan I.; Parasuraman, Shreekant; Pierce, Anna; Eichenfield, Lawrence F.; and Poulos, Christine, "Treatment preferences among patients with mild-to-moderate atopic dermatitis" (2023). GW Authored Works. Paper 4086.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/4086

Department

Dermatology