Case report: A patient with Delayed Sleep-Wake Phase Disorder and Optic Nerve Hypoplasia treated with tasimelteon: a case study

Document Type

Journal Article

Publication Date

1-1-2023

Journal

Frontiers in neuroscience

Volume

17

DOI

10.3389/fnins.2023.1287514

Keywords

Delayed Sleep-Wake Phase Disorder; Optic Nerve Hypoplasia; biological rhythms; circadian rhythm disorders; clinical trials research; delayed sleep; night owl; sleep/wake mechanisms

Abstract

UNLABELLED: We present a case of an adult female diagnosed with Delayed Sleep-Wake Phase Disorder (DSWPD) and Optic Nerve Hypoplasia (ONH), with a confirmed delayed Dim Light Melatonin Onset (DLMO), who reports the inability to fall asleep at their desired bedtime and obtain adequate sleep nightly, despite the ability to have a full night's sleep when not required to be up at a specific time for societal requirements. The participant was enrolled in an 11-month Open-Label Extension (OLE) following the randomized portion of a clinical study and was successfully treated with tasimelteon. DSWPD symptoms were resolved, and their previously delayed sleep-wake cycle was advanced. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/ct2/show/NCT04652882, identifier NCT04652882.

Department

Neurology

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