Silica-based microencapsulation used in topical dermatologic applications
Document Type
Journal Article
Publication Date
12-1-2023
Journal
Archives of dermatological research
Volume
315
Issue
10
DOI
10.1007/s00403-023-02725-z
Keywords
Amorphous silica; Dermatologic agents; Dermatological agents; Microencapsulation; Silicon compounds
Abstract
Microencapsulation has received extensive attention because of its various applications. Since its inception in the 1940s, this technology has been used across several areas, including the chemical, food, and pharmaceutical industries. Over-the-counter skin products often contain ingredients that readily and unevenly degrade upon contact with the skin. Enclosing these substances within a silica shell can enhance their stability and better regulate their delivery onto and into the skin. Silica microencapsulation uses silica as the matrix material into which ingredients can be embedded to form microcapsules. The FDA recognizes amorphous silica as a safe inorganic excipient and recently approved two new topical therapies for the treatment of rosacea and acne. The first approved formulation uses a novel silica-based controlled vehicle delivery technology to improve the stability of two active ingredients that are normally not able to be used in the same formulation due to potential instability and drug degradation. The formulation contains 3.0% benzoyl peroxide (BPO) and 0.1% tretinoin topical cream to treat acne vulgaris in adults and pediatric patients. The second formulation contains silica microencapsulated 5.0% BPO topical cream to treat inflammatory rosacea lesions in adults. Both formulations use the same amorphous silica sol-gel microencapsulation technology to improve formulation stability and skin compatibility parameters.
APA Citation
Green, Lawrence J.; Bhatia, Neal D.; Toledano, Ofer; Erlich, Maya; Spizuoco, Amy; Goodyear, Benjamin C.; York, Jean Philippe; and Jakus, Jeannette, "Silica-based microencapsulation used in topical dermatologic applications" (2023). GW Authored Works. Paper 3523.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/3523
Department
Dermatology