Limbic network co-localization predicts pharmacoresistance in dysplasia-related epilepsy

Authors

Nathan T. Cohen, Center for Neuroscience Research, Children's National Hospital, The George Washington University School of Medicine, Washington, DC, USA.
Phat Chang, Center for Neuroscience Research, Children's National Hospital, The George Washington University School of Medicine, Washington, DC, USA.
Taha Gholipour, Center for Neuroscience Research, Children's National Hospital, The George Washington University School of Medicine, Washington, DC, USA.
Chima Oluigbo, Center for Neuroscience Research, Children's National Hospital, The George Washington University School of Medicine, Washington, DC, USA.
L Gilbert Vezina, Center for Neuroscience Research, Children's National Hospital, The George Washington University School of Medicine, Washington, DC, USA.
Hua Xie, Center for Neuroscience Research, Children's National Hospital, The George Washington University School of Medicine, Washington, DC, USA.
Anqing Zhang, Division of Biostatistics and Study Methodology, Children's National Research Institute, Washington, DC, USA.
William D. Gaillard, Center for Neuroscience Research, Children's National Hospital, The George Washington University School of Medicine, Washington, DC, USA.

Document Type

Journal Article

Publication Date

9-12-2023

Journal

Annals of clinical and translational neurology

DOI

10.1002/acn3.51892

Abstract

To evaluate the role of focal cortical dysplasia co-localization to cortical functional networks in the development of pharmacoresistance. One hundred thirty-six focal cortical dysplasia patients with 3.0 T or 1.5 T MRI were identified from clinical databases at Children's National Hospital. Clinico-radio-pathologic factors and network co-localization were determined. Using binomial logistic regression, limbic network co-localization (odds ratio 4.164 95% confidence interval 1.02-17.08, p = 0.048), and focal to bilateral tonic-clonic seizures (4.82, 1.30-18.03, p = 0.019) predicted pharmacoresistance. These findings provide clinicians with markers to identify patients with focal cortical dysplasia-related epilepsy at high risk of developing pharmacoresistance and should facilitate earlier epilepsy surgical evaluation.

APA Citation

Cohen, Nathan T.; Chang, Phat; Gholipour, Taha; Oluigbo, Chima; Vezina, L Gilbert; Xie, Hua; Zhang, Anqing; and Gaillard, William D., "Limbic network co-localization predicts pharmacoresistance in dysplasia-related epilepsy" (2023). GW Authored Works. Paper 3421.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/3421

Department

Neurology