IL-15 and N-803 for HIV Cure Approaches

Authors

J Natalie Howard, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC 20037, USA.
Alberto Bosque, Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC 20037, USA.

Document Type

Journal Article

Publication Date

9-12-2023

Journal

Viruses

Volume

15

Issue

9

DOI

10.3390/v15091912

Keywords

HIV-1; IL-15; N-803; latency; reservoir; shock and kill

Abstract

In spite of the advances in antiretroviral therapy to treat HIV infection, the presence of a latent reservoir of HIV-infected cells represents the largest barrier towards finding a cure. Among the different strategies being pursued to eliminate or reduce this latent reservoir, the γc-cytokine IL-15 or its superagonist N-803 are currently under clinical investigation, either alone or with other interventions. They have been shown to reactivate latent HIV and enhance immune effector function, both of which are potentially required for effective reduction of latent reservoirs. In here, we present a comprehensive literature review of the different in vitro, ex vivo, and in vivo studies conducted to date that are aimed at targeting HIV reservoirs using IL-15 and N-803.

APA Citation

Howard, J Natalie and Bosque, Alberto, "IL-15 and N-803 for HIV Cure Approaches" (2023). GW Authored Works. Paper 3418.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/3418

Department

Microbiology, Immunology, and Tropical Medicine