The burden of chronic drug-refractory focal onset epilepsy: Can it be prevented?

Authors

Elinor Ben-Menachem, University of Gothenburg, Gothenburg, Sweden. Electronic address: elinor.ben-menachem@neuro.gu.se.
Bettina Schmitz, Neurology/Center for Epilepsy, Stroke Unit and Neurological Rehabilitation, Vivantes Humboldt Hospital, Berlin, Germany. Electronic address: Bettina.Schmitz@vivantes.de.
Reetta Kälviäinen, University of Eastern Finland, Finland. Electronic address: Reetta.Kalviainen@pshyvinvointialue.fi.
Thomas Rhys, Department of Neurology, Royal Victoria Infirmary, Queen Victoria Rd, Newcastle-Upon-Tyne NE1 4LP, United Kingdom; Translational and Clinical Research Institute, Henry Wellcome Building, Framlington Place, Newcastle-Upon-Tyne NE2 4HH, United Kingdom. Electronic address: Rhys.Thomas@newcastle.ac.uk.
Pavel Klein, Department of Neurology, George Washington University, Boston, United States. Electronic address: KleinP@Epilepsydc.com.

Document Type

Journal Article

Publication Date

9-23-2023

Journal

Epilepsy & behavior : E&B

Volume

148

DOI

10.1016/j.yebeh.2023.109435

Keywords

Add-on; Burden of disease; Drug-resistant epilepsy (DRE); Focal onset seizures; Quality of life (QoL); Third generation antiseizure medications (ASMs)

Abstract

Despite the many therapeutic options for epilepsy available today, a third of patients still have poorly controlled epilepsy. Over the years, their transition through lines of treatment exposes them to increased risk of disease progression, mortality, morbidity, mental distress, and not least significantly impaired quality of life (QoL). The present review explores the multiple factors contributing to the impairment of health-related QoL in PWE-including both seizure-related and non seizure-related. The analysis aims to identify potential areas of intervention and strategies for a more holistic approach to epilepsy care and inform policy-makers and healthcare providers in their approach to this condition.

APA Citation

Ben-Menachem, Elinor; Schmitz, Bettina; Kälviäinen, Reetta; Rhys, Thomas; and Klein, Pavel, "The burden of chronic drug-refractory focal onset epilepsy: Can it be prevented?" (2023). GW Authored Works. Paper 3355.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/3355

Department

Neurology