Maternal asthma in relation to infant size and body composition

Authors

Danielle R. Stevens, Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park.
Edwina Yeung, Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda.
Stefanie N. Hinkle, Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda.
William Grobman, Wexner Medical Center, The Ohio State University, Columbus.
Andrew Williams, School of Medicine and Health Sciences, University of North Dakota, Grand Forks.
Marion Ouidir, Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda.
Rajesh Kumar, Feinberg School of Medicine, Northwestern University, Chicago.
Leah M. Lipsky, Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda.
Matthew C. Rohn, Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda.
Jenna Kanner, Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda.
Seth Sherman, Emmes Company, Rockville.
Zhen Chen, Biostatistics Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda.
Pauline Mendola, Epidemiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda.

Document Type

Journal Article

Publication Date

8-1-2023

Journal

The journal of allergy and clinical immunology. Global

Volume

2

Issue

3

DOI

10.1016/j.jacig.2023.100122

Keywords

Infant; adiposity; anthropometry; asthma; atopy; pregnancy; prospective study

Abstract

BACKGROUND: Asthma affects 10% of pregnancies and may influence offspring health, including infant size and body composition, through hypoxic and inflammatory pathways. OBJECTIVE: We sought to determine associations between maternal asthma and asthma phenotypes during pregnancy and infant size and body composition. METHODS: The B-WELL-Mom study (2015-19) is a prospective cohort of 418 pregnant persons with and without asthma recruited in the first trimester of pregnancy from 2 US obstetric clinics. Exposures were maternal self-reported active asthma (n = 311) or no asthma (n = 107), and asthma phenotypes were classified on the bases of atopy, onset, exercise induced, control, severity, symptomology, and exacerbations. Outcomes were infant weight, length, head circumference, and skinfold measurements at birth and postnatal follow-up, as well as fat and lean mass assessed by air displacement plethysmography at birth. Adjusted multivariable linear regression examined associations of maternal asthma and asthma phenotypes with infant outcomes. RESULTS: Offspring were born at a mean ± SD of 38 ± 2.3 weeks' gestation and were 18 ± 2.2 weeks of age at postnatal follow-up. Infants of participants with asthma had a mean ± SD fat mass of 11.0 ± 4.2%, birth weight of 3045.8 ± 604.3 g, and postnatal follow-up weight of 6696.4 ± 964.2 g, which were not different from infants of participants without asthma (respectively, β [95% confidence interval]: -0.1 [-1.4, 1.3], -26.7 [-156.9, 103.4], and 107.5 [-117.3, 332.3]). Few associations were observed between asthma or asthma phenotypes and infant size or body composition. CONCLUSIONS: In a current obstetric cohort, maternal asthma during pregnancy was not associated with differential infant size or body composition.

APA Citation

Stevens, Danielle R.; Yeung, Edwina; Hinkle, Stefanie N.; Grobman, William; Williams, Andrew; Ouidir, Marion; Kumar, Rajesh; Lipsky, Leah M.; Rohn, Matthew C.; Kanner, Jenna; Sherman, Seth; Chen, Zhen; and Mendola, Pauline, "Maternal asthma in relation to infant size and body composition" (2023). GW Authored Works. Paper 3305.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/3305

Department

School of Medicine and Health Sciences Resident Works