Immunogenicity of a Two Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial

Authors

• Nadine G. Rouphael, Emory University Hope Clinic, Decatur, GA, USA.
• Angela R. Branche, University of Rochester VTEU, Rochester, NY, USA.
• David J. Diemert, George Washington Vaccine Research Unit, George Washington University, Washington DC, USA.
• Ann R. Falsey, University of Rochester VTEU, Rochester, NY, USA.
• Cecilia Losada, Emory University Hope Clinic, Decatur, GA, USA.
• Lindsey R. Baden, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
• Sharon E. Frey, Saint Louis University, Center for Vaccine Development, St. Louis, MO, USA.
• Jennifer A. Whitaker, Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston, TX, USA.
• Susan J. Little, Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA, USA.
• Satoshi Kamidani, Center for Childhood Infections and Vaccines (CCIV) of Children's Healthcare of Atlanta and Emory University Department of Pediatrics, Atlanta, GA, USA.
• Emmanuel B. Walter, Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.
• Richard M. Novak, University of Illinois at Chicago-Project WISH, Chicago, IL, USA.
• Richard Rupp, University of Texas Medical Branch, Galveston, TX, USA.
• Lisa A. Jackson, Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
• Tara M. Babu, Department of Medicine, Division of Allergy and Infectious Diseases, Seattle, WA, USA.
• Angelica C. Kottkamp, NYU VTEU Manhattan Research Clinic at NYU Grossman School of Medicine, New York, NY, USA.
• Anne F. Luetkemeyer, Zuckerberg San Francisco General, University of California San Francisco, San Francisco, CA, USA.
• Lilly C. Immergluck, Morehouse School of Medicine, Department of Microbiology/Biochemistry/Immunology and Clinical Research Center, Atlanta, GA, USA.
• Rachel M. Presti, Washington University School of Medicine, St. Louis, MO, USA.
• Martín Bäcker, NYU VTEU Long Island Research Clinic at NYU Long Island School of Medicine, Mineola, NY, USA.
• Patricia L. Winokur, University of Iowa College of Medicine, Iowa City, IA, USA.
• Siham M. Mahgoub, Howard University College of Medicine, Howard University Hospital, Washington DC, USA.
• Paul A. Goepfert, University of Alabama at Birmingham, Birmingham, AL, USA.
• Dahlene N. Fusco, Tulane University School of Medicine, New Orleans, LA, USA.
• Robert L. Atmar, Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston, TX, USA.
• Christine M. Posavad, IDCRC Laboratory Operations Unit -Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center and Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
• Antonia Netzl, Centre for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, UK.
• Derek J. Smith, Centre for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, UK.
• Kalyani Telu, The Emmes Company, LLC, Rockville, MD, USA.
• Jinjian Mu, The Emmes Company, LLC, Rockville, MD, USA.
• Lisa J. McQuarrie, The Emmes Company, LLC, Rockville, MD, USA.
• Mat Makowski, The Emmes Company, LLC, Rockville, MD, USA.

Document Type

Journal Article

Publication Date

8-10-2023

Journal

The Journal of infectious diseases

DOI

10.1093/infdis/jiad323

Keywords

SARS-CoV-2; Vaccine; Variant

Abstract

We compared the serologic responses of one versus two doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A two-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.

APA Citation

Rouphael, Nadine G.; Branche, Angela R.; Diemert, David J.; Falsey, Ann R.; Losada, Cecilia; Baden, Lindsey R.; Frey, Sharon E.; Whitaker, Jennifer A.; Little, Susan J.; Kamidani, Satoshi; Walter, Emmanuel B.; Novak, Richard M.; Rupp, Richard; Jackson, Lisa A.; Babu, Tara M.; Kottkamp, Angelica C.; Luetkemeyer, Anne F.; Immergluck, Lilly C.; Presti, Rachel M.; Bäcker, Martín; Winokur, Patricia L.; Mahgoub, Siham M.; Goepfert, Paul A.; Fusco, Dahlene N.; Atmar, Robert L.; Posavad, Christine M.; Netzl, Antonia; Smith, Derek J.; Telu, Kalyani; Mu, Jinjian; McQuarrie, Lisa J.; and Makowski, Mat, "Immunogenicity of a Two Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial" (2023). GW Authored Works. Paper 3266.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/3266

Department

Medicine