Immunogenicity of a Two Dose Regimen of Moderna mRNA Beta/Omicron BA.1 Bivalent Variant Vaccine Boost in a Randomized Clinical Trial

Nadine G. Rouphael, Emory University Hope Clinic, Decatur, GA, USA.
Angela R. Branche, University of Rochester VTEU, Rochester, NY, USA.
David J. Diemert, George Washington Vaccine Research Unit, George Washington University, Washington DC, USA.
Ann R. Falsey, University of Rochester VTEU, Rochester, NY, USA.
Cecilia Losada, Emory University Hope Clinic, Decatur, GA, USA.
Lindsey R. Baden, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sharon E. Frey, Saint Louis University, Center for Vaccine Development, St. Louis, MO, USA.
Jennifer A. Whitaker, Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston, TX, USA.
Susan J. Little, Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA, USA.
Satoshi Kamidani, Center for Childhood Infections and Vaccines (CCIV) of Children's Healthcare of Atlanta and Emory University Department of Pediatrics, Atlanta, GA, USA.
Emmanuel B. Walter, Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC, USA.
Richard M. Novak, University of Illinois at Chicago-Project WISH, Chicago, IL, USA.
Richard Rupp, University of Texas Medical Branch, Galveston, TX, USA.
Lisa A. Jackson, Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Tara M. Babu, Department of Medicine, Division of Allergy and Infectious Diseases, Seattle, WA, USA.
Angelica C. Kottkamp, NYU VTEU Manhattan Research Clinic at NYU Grossman School of Medicine, New York, NY, USA.
Anne F. Luetkemeyer, Zuckerberg San Francisco General, University of California San Francisco, San Francisco, CA, USA.
Lilly C. Immergluck, Morehouse School of Medicine, Department of Microbiology/Biochemistry/Immunology and Clinical Research Center, Atlanta, GA, USA.
Rachel M. Presti, Washington University School of Medicine, St. Louis, MO, USA.
Martín Bäcker, NYU VTEU Long Island Research Clinic at NYU Long Island School of Medicine, Mineola, NY, USA.
Patricia L. Winokur, University of Iowa College of Medicine, Iowa City, IA, USA.
Siham M. Mahgoub, Howard University College of Medicine, Howard University Hospital, Washington DC, USA.
Paul A. Goepfert, University of Alabama at Birmingham, Birmingham, AL, USA.
Dahlene N. Fusco, Tulane University School of Medicine, New Orleans, LA, USA.
Robert L. Atmar, Departments of Molecular Virology and Microbiology and Medicine, Baylor College of Medicine, Houston, TX, USA.
Christine M. Posavad, IDCRC Laboratory Operations Unit -Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center and Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Antonia Netzl, Centre for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, UK.
Derek J. Smith, Centre for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, UK.
Kalyani Telu, The Emmes Company, LLC, Rockville, MD, USA.
Jinjian Mu, The Emmes Company, LLC, Rockville, MD, USA.
Lisa J. McQuarrie, The Emmes Company, LLC, Rockville, MD, USA.
Mat Makowski, The Emmes Company, LLC, Rockville, MD, USA.

Document Type

Journal Article

Publication Date

8-10-2023

Journal

The Journal of infectious diseases

DOI

10.1093/infdis/jiad323

Keywords

SARS-CoV-2; Vaccine; Variant

Abstract

We compared the serologic responses of one versus two doses of a variant vaccine (Moderna mRNA-1273 Beta/Omicron BA.1 bivalent vaccine) in adults. A two-dose boosting regimen with a variant vaccine did not increase the magnitude or the durability of the serological responses compared to a single variant vaccine boost.

Department

Medicine

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